J Michael Ruppert
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Explore the profile of J Michael Ruppert including associated specialties, affiliations and a list of published articles.
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22
Citations
939
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Recent Articles
1.
Ren A, Snellings D, Su Y, Hong C, Castro M, Tang A, et al.
Nature
. 2021 Apr;
594(7862):271-276.
PMID: 33910229
Vascular malformations are thought to be monogenic disorders that result in dysregulated growth of blood vessels. In the brain, cerebral cavernous malformations (CCMs) arise owing to inactivation of the endothelial...
2.
Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis
Addison J, Voronkova M, Fugett J, Lin C, Linville N, Trinh B, et al.
Mol Cancer Res
. 2021 Jan;
19(5):784-798.
PMID: 33500360
Several master transcription factors (TF) can activate the epithelial-to-mesenchymal transition (EMT). However, their individual and combinatorial contributions to EMT in breast cancer are not defined. We show that overexpression of...
3.
Zhao H, Martin E, Matalkah F, Shah N, Ivanov A, Ruppert J, et al.
Oncogene
. 2018 Nov;
38(13):2275-2290.
PMID: 30467378
Overexpression of the human epidermal growth factor receptor 2 (HER2) is the cause of HER2-positive breast cancer (BC). Although HER2-inactivating therapies have benefited BC patients, development of resistance and disease...
4.
Farrugia M, Vanderbilt D, Salkeni M, Ruppert J
Cancer Res
. 2016 Mar;
76(7):1677-82.
PMID: 26964625
Tumor cells inherit from their normal precursors an extensive stress response machinery that is critical for survival in response to challenges including oxidative stress, wounding, and shear stress. Kruppel-like transcription...
5.
Deng W, Vanderbilt D, Lin C, Martin K, Brundage K, Ruppert J
J Cell Sci
. 2015 Jan;
128(6):1123-38.
PMID: 25632159
The high mobility group box protein SOX9 and the GLI1 transcription factor play protumorigenic roles in pancreatic ductal adenocarcinoma (PDA). In Kras transgenic mice, each of these factors are crucial...
6.
Addison J, Koontz C, Fugett J, Creighton C, Chen D, Farrugia M, et al.
Cancer Res
. 2014 Nov;
75(2):344-55.
PMID: 25421577
KAP1 (TRIM28) is a transcriptional regulator in embryonic development that controls stem cell self-renewal, chromatin organization, and the DNA damage response, acting as an essential corepressor for KRAB family zinc...
7.
Sharma S, Lin C, Farrugia M, McLaughlin S, Ellis E, Brundage K, et al.
Mol Cell Biol
. 2014 Sep;
34(22):4143-64.
PMID: 25202123
Despite the low prevalence of activating point mutation of RAS or RAF genes, the RAS-extracellular signal-regulated kinase (ERK) pathway is implicated in breast cancer pathogenesis. Indeed, in triple-negative breast cancer...
8.
Adair-Kirk T, Griffin G, Meyer M, Kelley D, Miner J, Keene D, et al.
PLoS One
. 2012 Oct;
7(9):e45546.
PMID: 23029085
Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin chains. Laminin-332 modulates epithelial cell processes, such as adhesion, migration, and differentiation and is prominent...
9.
Lin C, Liu L, Addison J, Wonderlin W, Ivanov A, Ruppert J
Mol Cell Biol
. 2011 Apr;
31(12):2513-27.
PMID: 21518959
Krüppel-like factor 4 (KLF4), a transcription factor that regulates cell fate in a context-dependent fashion, is normally induced upon growth arrest or differentiation. In many cancer cells there is dysregulation,...
10.
Liu Z, Teng L, Bailey S, Frost A, Bland K, LoBuglio A, et al.
Cancer Biol Ther
. 2009 Sep;
8(19):1840-51.
PMID: 19717984
The transcription factors Notch1 and KLF4 specify epithelial cell fates and confer stem cell properties. Suggesting a functional relationship, each gene can act to promote or suppress tumorigenesis in a...