J M Shifman
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Explore the profile of J M Shifman including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
101
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Recent Articles
1.
Shifman J, Gibney B, Sharp R, Dutton P
Biochemistry
. 2000 Dec;
39(48):14813-21.
PMID: 11101297
The effects of various mechanisms of metalloporphyrin reduction potential modulation were investigated experimentally using a robust, well-characterized heme protein maquette, synthetic protein scaffold H10A24 [¿CH(3)()CONH-CGGGELWKL.HEELLKK.FEELLKL.AEERLKK. L-CONH(2)()¿(2)](2). Removal of the iron...
2.
Shimaoka M, Shifman J, Jing H, Takagi J, Mayo S, Springer T
Nat Struct Biol
. 2000 Aug;
7(8):674-8.
PMID: 10932253
We have taken a computational approach to design mutations that stabilize a large protein domain of approximately 200 residues in two alternative conformations. Mutations in the hydrophobic core of the...
3.
Shifman J, Moser C, Kalsbeck W, Bocian D, Dutton P
Biochemistry
. 1998 Dec;
37(47):16815-27.
PMID: 9843452
Proton exchange with aqueous media coupled to heme oxidation/reduction is commonly seen but not understood in natural cytochromes. Our synthetic tetrahelix bundle heme protein maquettes successfully reproduce natural proton coupling...