J M Pawelek
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Explore the profile of J M Pawelek including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Chakraborty A, Pawelek J
Biochem Biophys Res Commun
. 1992 Nov;
188(3):1325-31.
PMID: 1445364
MSH can up-regulate MSH binding capacity of cultured Cloudman melanoma cells in a dose- and time-dependent fashion. Binding is mediated through proteins exhibiting an apparent molecular weight of 50-53kDa, consistent...
22.
Pawelek J, Chakraborty A, Osber M, Orlow S, Min K, Rosenzweig K, et al.
Pigment Cell Res
. 1992 Nov;
5(5 Pt 2):348-56.
PMID: 1292019
When human skin is exposed to ultraviolet (UV) light, a highly complex cascade of events ensues that culminates, among other things, in increased skin melanin content. From analyses at the...
23.
Orlow S, Osber M, Pawelek J
Pigment Cell Res
. 1992 Sep;
5(3):113-21.
PMID: 1409448
Several studies have confirmed that a melanocyte-specific enzyme, dopachrome tautomerase (EC 5.3.2.3), catalyzes the isomerization of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (Pawelek, 1991). Here we report that DHICA, produced either...
24.
Chakraborty A, Orlow S, Pawelek J
FEBS Lett
. 1992 May;
302(2):126-8.
PMID: 1633843
Dopachrome tautomerase (DT) (EC 5.3.2.3) is a melanocyte-specific, membrane-associated, heat-labile, non-dialyzable, protease-sensitive factor which catalyzes the isomeric rearrangement of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA), apparently through a tautomerization reaction. Metal...
25.
Orlow S, Chakraborty A, Pawelek J
Pigment Cell Res
. 1992 Jan;
Suppl 2:162-70.
PMID: 1384030
No abstract available.
26.
Chakraborty A, Orlow S, Bolognia J, Pawelek J
J Cell Physiol
. 1991 Apr;
147(1):1-6.
PMID: 1903794
Expression of internal receptors for MSH is an important criterion for responsiveness to MSH by Cloudman melanoma cells (Orlow et al: J. Cell. Physiol., 142:129-136, 1990). Here, we show that...
27.
Pawelek J
Pigment Cell Res
. 1991 Mar;
4(2):53-62.
PMID: 1946209
Dopachrome, an intermediate in melanin biosynthesis, exhibits some unusual properties. At physiologic pH (e.g., pH 6-8) it is unstable and spontaneously loses its carboxyl group to form 5,6-dihydroxyindole (DHI) and...
28.
Chakraborty A, Orlow S, Pawelek J
FEBS Lett
. 1990 Dec;
276(1-2):205-8.
PMID: 2265702
Treatment of Cloudman S91 melanoma cells with retinoic acid (RA) inhibits MSH-induced tyrosinase activity and melanin formation [(1990) J. Invest. Dermatol. 94, 461-464]. We report here, however, that in spite...
29.
Orlow S, Chakraborty A, Boissy R, Pawelek J
Exp Cell Res
. 1990 Dec;
191(2):209-18.
PMID: 1701721
Retinoic acid, hexamethylene bisacetamide, sodium butyrate, and dimethylsulfoxide, four compounds which modulate phenotypic expression in a variety of neoplastic cell lines, all inhibited the induction of tyrosinase activity and melanogenesis...
30.
Bolognia J, Murray M, Pawelek J
Pigment Cell Res
. 1990 Sep;
3(3):150-6.
PMID: 2290786
A stock of hairless pigmented guinea pigs was developed to facilitate studies of mammalian pigmentation. This stock combines the convenience of a hairless animal with a pigmentary system that is...