J M Miyashiro
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Explore the profile of J M Miyashiro including associated specialties, affiliations and a list of published articles.
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7
Citations
641
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Recent Articles
1.
Penning T, Chandrakumar N, Chen B, Chen H, Desai B, Djuric S, et al.
J Med Chem
. 2000 Feb;
43(4):721-35.
PMID: 10691697
Leukotriene B(4) (LTB(4)) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. Since the action of...
2.
Khanna I, Weier R, Yu Y, Collins P, Miyashiro J, Koboldt C, et al.
J Med Chem
. 1997 May;
40(11):1619-33.
PMID: 9171872
Series of 1,2-diarylpyrroles has been synthesized and found to contain very potent and selective inhibitors of the human cyclooxygenase-2 (COX-2) enzyme. The paper describes short and practical syntheses of the...
3.
Penning T, Talley J, Bertenshaw S, Carter J, Collins P, Docter S, et al.
J Med Chem
. 1997 Apr;
40(9):1347-65.
PMID: 9135032
A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive structure-activity relationship (SAR) work was carried out...
4.
Kurumbail R, Stevens A, Gierse J, McDonald J, Stegeman R, Pak J, et al.
Nature
. 1996 Dec;
384(6610):644-8.
PMID: 8967954
Prostaglandins and glucocorticoids are potent mediators of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) exert their effects by inhibition of prostaglandin production. The pharmacological target of NSAIDs is cyclooxygenase (COX, also known...
5.
Penning T, Djuric S, Miyashiro J, Yu S, Snyder J, Spangler D, et al.
J Med Chem
. 1995 Mar;
38(6):858-68.
PMID: 7699700
Our previous reports have highlighted the first-generation leukotriene B4 (LTB4) receptor antagonist SC-41930 (7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]3,4- dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid) which has potent oral, topical, and intracolonic activity in various animal models of inflammation....
6.
Fretland D, Widomski D, Shone R, Penning T, Miyashiro J, Djuric S
Prostaglandins Leukot Essent Fatty Acids
. 1989 Dec;
38(3):169-72.
PMID: 2560200
Psoriasis is a disease state characterized by epidermal proliferation, neutrophil infiltration, along with release of the proinflammatory mediators leukotriene-B4 (LTB4) and 12(R)-hydroxyeicosatetraenoic acid [12(R)-HETE]. LTB4 and 12(R)-HETE are chemoattractant to...
7.
Fretland D, Widomski D, Zemaitis J, Tsai B, Djuric S, Penning T, et al.
Prostaglandins Leukot Essent Fatty Acids
. 1989 Aug;
37(2):79-81.
PMID: 2550970
Psoriasis is a disease state characterized by epidermal proliferation, neutrophil infiltration, along with release of the proinflammatory mediators leukotriene-B4(LTB4) and 12(R)-hydroxyeicosatetraenoic acid [12(R)-HETE]. LTB4 and 12(R)-HETE are chemoattractant to the...