J M Jault
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Explore the profile of J M Jault including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
502
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Recent Articles
1.
Gobet A, Moissonnier L, Zarkadas E, Magnard S, Bettler E, Martin J, et al.
Nat Commun
. 2025 Feb;
16(1):1745.
PMID: 39966360
Multidrug ABC transporters harness the energy of ATP binding and hydrolysis to translocate substrates out of the cell and detoxify them. While this involves a well-accepted alternating access mechanism, molecular...
2.
di Pietro A, Conseil G, Perez-Victoria J, Dayan G, Baubichon-Cortay H, Trompier D, et al.
Cell Mol Life Sci
. 2002 Mar;
59(2):307-22.
PMID: 11915946
Cancer cell resistance to chemotherapy is often mediated by overexpression of P-glycoprotein, a plasma membrane ABC (ATP-binding cassette) transporter which extrudes cytotoxic drugs at the expense of ATP hydrolysis. P-glycoprotein...
3.
Geourjon C, Orelle C, Steinfels E, Blanchet C, Deleage G, di Pietro A, et al.
Trends Biochem Sci
. 2001 Sep;
26(9):539-44.
PMID: 11551790
ABC (ATP-binding cassette) transporters and helicases are large superfamilies of seemingly unrelated proteins, whose functions depend on the energy provided by ATP hydrolysis. Comparison of the 3D structures of their...
4.
De Wet H, McIntosh D, Conseil G, Baubichon-Cortay H, Krell T, Jault J, et al.
Biochemistry
. 2001 Aug;
40(34):10382-91.
PMID: 11513617
Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain (NBD2) of mouse P-glycoprotein were investigated by using two recombinantly expressed soluble proteins of different lengths and photoactive ATP...
5.
Conseil G, Perez-Victoria J, Jault J, Gamarro F, Goffeau A, Hofmann J, et al.
Biochemistry
. 2001 May;
40(8):2564-71.
PMID: 11327879
P-Glycoprotein and homologous multidrug transporters contain a phosphorylatable linker sequence that was proposed to control drug efflux on the basis that it was indeed phosphorylated in vitro and in vivo,...
6.
Oudot C, Cortay J, Blanchet C, LaPorte D, di Pietro A, Cozzone A, et al.
Biochemistry
. 2001 Mar;
40(10):3047-55.
PMID: 11258918
The isocitrate dehydrogenase kinase/phosphatase (IDHK/P) of E. coli is a bifunctional enzyme responsible for the reversible phosphorylation of isocitrate dehydrogenase (IDH) on a seryl residue. As such, it belongs to...
7.
Gonzalo P, Sontag B, Lavergne J, Jault J, REBOUD J
Biochemistry
. 2000 Nov;
39(44):13558-64.
PMID: 11063593
The rat elongation factor eEF-2 catalyzes the translocation step of protein synthesis. Besides its well-characterized GTP/GDP binding properties, we have previously shown that ATP and ADP bind to eEF-2 [Sontag,...
8.
Conseil G, Decottignies A, Jault J, Comte G, Barron D, Goffeau A, et al.
Biochemistry
. 2000 Jun;
39(23):6910-7.
PMID: 10841772
The Pdr5p multidrug ABC ("ATP-binding cassette) transporter was highly overexpressed in plasma membranes from a yeast strain exhibiting both pdr1-3 gain-of-function mutation in the transcription factor-encoding gene PDR1 and disruption...
9.
Jault J, Fieulaine S, Nessler S, Gonzalo P, di Pietro A, Deutscher J, et al.
J Biol Chem
. 2000 Jan;
275(3):1773-80.
PMID: 10636874
Carbon catabolite repression allows bacteria to rapidly alter the expression of catabolic genes in response to the availability of metabolizable carbon sources. In Bacillus subtilis, this phenomenon is controlled by...
10.
Oudot C, Jaquinod M, Cortay J, Cozzone A, Jault J
Eur J Biochem
. 1999 May;
262(1):224-9.
PMID: 10231385
Isocitrate dehydrogenase kinase/phosphatase (IDHK/P) is a homodimeric enzyme which controls the oxidative metabolism of Escherichia coli, and exibits a high intrinsic ATPase activity. When subjected to electrophoresis under nonreducing conditions,...