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J M Herbert

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Articles 207
Citations 4606
Followers 0
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Recent Articles
1.
Delesque-Touchard N, Pflieger A, Bonnet-Lignon S, Millet L, Salel V, Boldron C, et al.
Thromb Res . 2014 Jul; 134(3):693-703. PMID: 25064036
P2Y12 antagonism is a key therapeutic strategy in the management and prevention of arterial thrombosis. The objective of this study was to characterize the pharmacodynamic (PD) and pharmacokinetic (PK) properties...
2.
Herbert J, Bernat A, Savi P
Platelets . 2010 Nov; 6(6):412-3. PMID: 21043774
No abstract available.
3.
Savi P, Herault J, Duchaussoy P, Millet L, Schaeffer P, Petitou M, et al.
J Thromb Haemost . 2008 Jul; 6(10):1697-706. PMID: 18647228
Objective: In order to obtain a neutralizable antithrombotic, a chimeric molecule (SSR126517E) containing the sequence of a long-lasting antithrombin (AT)-dependent anti-factor Xa pentasaccharide, idraparinux, linked to a biotin molecule was...
4.
Savi P, Nurden P, Nurden A, Levy-Toledano S, Herbert J
Platelets . 2006 Jun; 9(3-4):251-5. PMID: 16793712
The search for active antiplatelet drugs within the original chemical class of the thienopyridines, led to the discovery of clopidogrel, a novel ADP-selective agent whose antiaggregating properties are several times...
5.
Bal Dit Sollier C, Kang C, Berge N, Herault J, Bonneau M, Herbert J, et al.
J Thromb Haemost . 2004 May; 2(6):925-30. PMID: 15140128
The activity of SanOrg123781A, a new synthetic antithrombotic drug inhibiting both factor Xa and thrombin through antithrombin (AT), was compared to that of unfractionated heparin (UFH) and of the synthetic...
6.
Soulet C, Sauzeau V, Plantavid M, Herbert J, Pacaud P, Payrastre B, et al.
J Thromb Haemost . 2004 Jan; 2(1):135-46. PMID: 14717977
The P2Y12 ADP receptor is one of the major regulators of platelet activation and the target of antithrombotic thienopyridines (ticlopidine and clopidogrel). It has been recently cloned but the signaling...
7.
Vin V, Leducq N, Bono F, Herbert J
Biochem Biophys Res Commun . 2003 Oct; 310(3):785-90. PMID: 14550272
The peripheral benzodiazepine receptor (PBR), has been recently shown to play a key role in the regulation of the mitochondrial process leading to apoptosis, which occurs during cardiac ischemia. The...
8.
Pottier P, Planchon B, Truchaud F, Leftheriotis G, Herbert J, Bressollette L, et al.
Blood Coagul Fibrinolysis . 2003 Sep; 14(6):587-91. PMID: 12960613
On a previous model using Wessler's principle in the rat, we have demonstrated that a partial ligature of the inferior vena cava leading to a 40% increase in up-stream venous...
9.
Ray J, Leach R, Herbert J, Benson M
Methods Cell Sci . 2002 Dec; 23(4):185-8. PMID: 12486328
The vascular smooth muscle cell plays a significant role in many important cardiovascular disorders, and smooth muscle biology is therefore important to cardiovascular research. The mouse is critical to basic...
10.
Leger P, Cambus J, Herault J, Herbert J, Boneu B
Thromb Haemost . 2002 Oct; 88(4):687-8. PMID: 12362245
No abstract available.