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J M Gubbens-Stibbe

Explore the profile of J M Gubbens-Stibbe including associated specialties, affiliations and a list of published articles. Areas
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1.
Visser S, Wolters F, Gubbens-Stibbe J, Tukker E, van der Graaf P, Peletier L, et al.
J Pharmacol Exp Ther . 2002 Dec; 304(1):88-101. PMID: 12490579
A mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) model for neuroactive steroids, comprising a separate characterization of 1) the receptor activation process and 2) the stimulus-response relationship, was applied to various nonsteroidal GABAA receptor...
2.
Cox E, Langemeijer M, Gubbens-Stibbe J, Muir K, Danhof M
Anesthesiology . 1999 Feb; 90(2):535-44. PMID: 9952162
Background: The purpose of this study was to investigate the in vivo pharmacodynamics and the pharmacodynamic interactions of remifentanil and its major metabolite, GR90291, in a rat electroencephalographic model. Methods:...
3.
van der Geest R, van Laar T, Kruger P, Gubbens-Stibbe J, Bodde H, Roos R, et al.
Clin Neuropharmacol . 1998 Jun; 21(3):159-68. PMID: 9617507
The pharmacokinetics and metabolism of R-apomorphine were determined in 10 patients with idiopathic Parkinson's disease after intravenous infusion of 30 micrograms.kg-1 in 15 min. Specifically, emphasis was on enantiomeric interconversion...
4.
van der Geest R, van Laar T, Gubbens-Stibbe J, Bodde H, Danhof M
Pharm Res . 1998 Feb; 14(12):1804-10. PMID: 9453072
Purpose: Transdermal transport rates of the dopamine agonist R-apomorphine were determined in patients with idiopathic Parkinson's disease (IPD). Apomorphine was applied by iontophoresis at two current densities. Methods: In ten...
5.
van der Geest R, Kruger P, Gubbens-Stibbe J, van Laar T, Bodde H, Danhof M
J Chromatogr B Biomed Sci Appl . 1998 Feb; 702(1-2):131-41. PMID: 9449564
Analytical methods are described for the selective, rapid and sensitive determination of R- and S-apomorphine, apocodeine and isoapocodeine and the glucuronic acid and sulfate conjugates in plasma and urine. The...
6.
van Schaick E, Gubbens-Stibbe J, Langemeijer M, Roelen H, IJzerman A, Danhof M
J Pharmacol Exp Ther . 1997 Nov; 283(2):800-8. PMID: 9353401
Partial adenosine A1 receptor agonists with reduced intrinsic activity at the cardiovascular system would be promising for therapeutic application (e.g., as antilipolytic agents). In the present study a series of...
7.
Mathot R, Gubbens-Stibbe J, Soudijn W, Jacobson K, IJzerman A, Danhof M
J Pharmacol Exp Ther . 1995 Oct; 275(1):245-53. PMID: 7562557
The purpose of the present study was to quantify the in vivo potency of the selective adenosine A2a antagonist CSC [8-(3-chlorostyryl)caffeine]. Four groups of conscious, normotensive rats received a continuous...
8.
Mandema J, Gubbens-Stibbe J, Danhof M
Psychopharmacology (Berl) . 1991 Jan; 103(3):384-7. PMID: 2057540
The pharmacokinetics of flumazenil in the rat were determined after 2.5 mg/kg intravenous and 25 mg/kg oral administration. Following intravenous administration flumazenil was rapidly eliminated with an extremely short terminal...
9.
van den Berg G, van Steveninck F, Gubbens-Stibbe J, Schoemaker H, De Boer A, Cohen A
Eur J Clin Pharmacol . 1990 Jan; 39(3):315-6. PMID: 2257873
The influence of food intake on the bioavailability of metoprolol from an OROS system has been investigated. No significant difference was found between OROS administration to fasting subjects or after...
10.
De Boer A, Breimer D, Gubbens-Stibbe J, Bosma A
Biopharm Drug Dispos . 1983 Oct; 4(4):321-30. PMID: 6689276
In order to study the avoidance of hepatic first-pass elimination following rectal administration, 500 mg of salicylamide (SAM) were given orally and rectally to man. Plasma SAM concentrations were measurable...