J M Downey
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Explore the profile of J M Downey including associated specialties, affiliations and a list of published articles.
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194
Citations
3324
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Recent Articles
1.
Bell R, Botker H, Carr R, Davidson S, Downey J, Dutka D, et al.
Basic Res Cardiol
. 2016 May;
111(4):41.
PMID: 27164905
In the 30 years since the original description of ischaemic preconditioning, understanding of the pathophysiology of ischaemia/reperfusion injury and concepts of cardioprotection have been revolutionised. In the same period of...
2.
Bell R, Sivaraman V, Kunuthur S, Cohen M, Downey J, Yellon D
Cardiovasc Drugs Ther
. 2015 Jul;
29(5):415-8.
PMID: 26179955
No abstract available.
3.
Downey J
Trends Cardiovasc Med
. 2011 Jan;
2(5):170-6.
PMID: 21239250
A brief exposure to ischemia paradoxically makes the heart better able to withstand a subsequent ischemic insult. This phenomenon has been termed ischemic preconditioning. Recent studies indicate that occupancy of...
4.
Tissier R, Cohen M, Downey J
Arch Mal Coeur Vaiss
. 2007 Nov;
100(9):794-802.
PMID: 18033009
Patients currently treated for acute myocardial infarction receive reperfusion therapy as their only anti-infarct intervention. Although pharmacologic agents have been evaluated in the past for their ability to salvage ischemic...
5.
Cohen M, Downey J
Br J Pharmacol
. 2007 Sep;
152(6):833-4.
PMID: 17876305
Classical ischaemic preconditioning, delayed or second window preconditioning and postconditioning are forms of cardioprotection that are dependent on cell surface receptors, intracellular signalling molecules and kinases that ultimately block formation...
6.
Solenkova N, Maslov L, Downey J
Patol Fiziol Eksp Ter
. 2006 Jul;
(2):28-31.
PMID: 16841658
No abstract available.
7.
Platonov A, Lasukova T, Maslov L, Downey J, Nagaze H, Ovchinnikov M
Eksp Klin Farmakol
. 2005 Feb;
67(6):26-9.
PMID: 15707010
Pretreatment with selective delta-opioid receptor (delta-OR) agonists decreased the level of creatine kinase in the coronary effluent of isolated rat heart during a 45-min global ischemia and a 30-min reperfusion....
8.
Krieg T, Yang X, Downey J, Schaffer S, Cohen M
Amino Acids
. 2004 Jun;
26(3):263-6.
PMID: 15221506
In ischemic preconditioning (IPC) a brief ischemic period protects the heart from a subsequent ischemic insult by an unknown mechanism. Osmotic swelling has been proposed to be a major cause...
9.
10.
Xu Z, Cohen M, Downey J, Vanden Hoek T, Yao Z
Am J Physiol Heart Circ Physiol
. 2001 Nov;
281(6):H2585-9.
PMID: 11709426
AMP 579, an adenosine A(1)/A(2) receptor agonist, has a strong anti-infarct effect when administered just before reperfusion. Because oxidative stress has been proposed to contribute to myocardial reperfusion injury, we...