J Lacadena
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Explore the profile of J Lacadena including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
278
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Recent Articles
1.
Lazaro-Gorines R, Ruiz-de-la-Herran J, Navarro R, Sanz L, Alvarez-Vallina L, Martinez-Del-Pozo A, et al.
Sci Rep
. 2019 Aug;
9(1):11680.
PMID: 31406218
Immunotoxins are chimeric molecules, which combine antibody specificity to recognize and bind with high-affinity tumor-associated antigens (TAA) with the potency of the enzymatic activity of a toxin, in order to...
2.
Calonge W, Martinez L, Lacadena J, Fernandez-Dumont V, Matesanz R, Tovar J
Pediatr Surg Int
. 2007 Jan;
23(5):419-24.
PMID: 17211587
Exposure of rat and mouse embryos to adriamycin (doxorubicin chlorhydrate) induces esophageal atresia (EA) and VACTERL association. Sonic hedgehog (Shh) and Gli2/Gli3 pathways are involved in these conditions and knockout...
3.
Masip M, Lacadena J, Mancheno J, Onaderra M, Martinez-Ruiz A, del Pozo A, et al.
Eur J Biochem
. 2001 Dec;
268(23):6190-6.
PMID: 11733014
Alpha-sarcin, a cyclizing ribonuclease secreted by the mould Aspergillus giganteus, is one of the best characterized members of a family of fungal ribotoxins. This protein induces apoptosis in tumour cells...
4.
Martinez-Ruiz A, Garcia-Ortega L, Kao R, Lacadena J, Onaderra M, Mancheno J, et al.
Methods Enzymol
. 2001 Oct;
341:335-51.
PMID: 11582789
No abstract available.
5.
Garcia-Ortega L, Lacadena J, Mancheno J, Onaderra M, Kao R, Davies J, et al.
Protein Sci
. 2001 Jul;
10(8):1658-68.
PMID: 11468362
Ribotoxins are a family of potent cytotoxic proteins from Aspergillus whose members display a high sequence identity (85% for about 150 amino acid residues). The three-dimensional structures of two of...
6.
de Antonio C, del Pozo A, Mancheno J, Onaderra M, Lacadena J, Martinez-Ruiz A, et al.
Proteins
. 2000 Oct;
41(3):350-61.
PMID: 11025546
alpha-Sarcin, a potent cytotoxic protein from Aspergillus giganteus, contains two tryptophan residues at positions 4 and 51. Two single, W4F and W51F, and the double mutant, W4/51F, have been produced...
7.
Santoro J, Campos-Olivas R, Lacadena J, del Pozo A, Gavilanes J, Rico M, et al.
J Mol Biol
. 2000 Jun;
299(4):1061-73.
PMID: 10843858
alpha-Sarcin selectively cleaves a single phosphodiester bond in a universally conserved sequence of the major rRNA, that inactivates the ribosome. The elucidation of the three-dimensional solution structure of this 150...
8.
Garcia-Ortega L, Lacadena J, Lacadena V, Masip M, de Antonio C, Martinez-Ruiz A, et al.
Lett Appl Microbiol
. 2000 May;
30(4):298-302.
PMID: 10792650
The yield of purified recombinant alpha-sarcin increases approximately three- to fourfold when this toxin is co-expressed in Escherichia coli with thioredoxin. This increased production is attributed to the existence, in...
9.
de los Rios V, Onaderra M, Martinez-Ruiz A, Lacadena J, Mancheno J, del Pozo A, et al.
Protein Expr Purif
. 2000 Jan;
18(1):71-6.
PMID: 10648171
The cDNA coding for the cytolytic toxins sticholysin I and sticholysin II from the sea anemone Stichodactyla helianthus has been isolated, cloned in pUC18, and sequenced. A 6His-tagged version of...
10.
Lacadena J, del Pozo A, Martinez-Ruiz A, Bruix M, Mancheno J, Onaderra M, et al.
Proteins
. 1999 Dec;
37(3):474-84.
PMID: 10591106
alpha-Sarcin is a ribotoxin secreted by the mold Aspergillus giganteus that degrades the ribosomal RNA by acting as a cyclizing ribonuclease. Three residues potentially involved in the mechanism of catalysis--histidine-50,...