J L Rapoport
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Explore the profile of J L Rapoport including associated specialties, affiliations and a list of published articles.
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294
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Recent Articles
1.
Anvari A, Friedman L, Greenstein D, Gochman P, Gogtay N, Rapoport J
Psychol Med
. 2015 May;
45(12):2667-74.
PMID: 25936396
Background: Fixed hippocampal volume reductions and shape abnormalities are established findings in schizophrenia, but the relationship between hippocampal volume change and clinical outcome has been relatively unexplored in schizophrenia and...
2.
Kano S, Yuan M, Cardarelli R, Maegawa G, Higurashi N, Gaval-Cruz M, et al.
Curr Mol Med
. 2015 Mar;
15(2):138-45.
PMID: 25732146
Methodologies for generating functional neuronal cells directly from human fibroblasts [induced neuronal (iN) cells] have been recently developed, but the research so far has only focused on technical refinements or...
3.
Ahn K, An S, Shugart Y, Rapoport J
Mol Psychiatry
. 2014 Dec;
21(1):94-6.
PMID: 25510512
Childhood-onset schizophrenia (COS) is a rare and severe form of the disorder, with more striking abnormalities with respect to prepsychotic developmental disorders and abnormities in the brain development compared with...
4.
Casey B, Trainor R, Orendi J, Schubert A, Nystrom L, Giedd J, et al.
J Cogn Neurosci
. 2013 Aug;
9(6):835-47.
PMID: 23964603
This study examines important developmental differences in patterns of activation in the prefrontal cortex during performance of a Go-No-Go paradigm using functional magnetic resonance imaging (fMRI). Eighteen subjects (9 children...
5.
Ahn K, Gotay N, Andersen T, Anvari A, Gochman P, Lee Y, et al.
Mol Psychiatry
. 2013 May;
19(5):568-72.
PMID: 23689535
Copy number variants (CNVs) are risk factors in neurodevelopmental disorders, including autism, epilepsy, intellectual disability (ID) and schizophrenia. Childhood onset schizophrenia (COS), defined as onset before the age of 13...
6.
Tarabeux J, Kebir O, Gauthier J, Hamdan F, Xiong L, Piton A, et al.
Transl Psychiatry
. 2012 Jul;
1:e55.
PMID: 22833210
Pharmacological, genetic and expression studies implicate N-methyl-D-aspartate (NMDA) receptor hypofunction in schizophrenia (SCZ). Similarly, several lines of evidence suggest that autism spectrum disorders (ASD) could be due to an imbalance...
7.
Rapoport J, Giedd J, Gogtay N
Mol Psychiatry
. 2012 Apr;
17(12):1228-38.
PMID: 22488257
The neurodevelopmental model of schizophrenia, which posits that the illness is the end state of abnormal neurodevelopmental processes that started years before the illness onset, is widely accepted, and has...
8.
Nguyen L, Jolly L, Shoubridge C, Chan W, Huang L, Laumonnier F, et al.
Mol Psychiatry
. 2011 Dec;
17(11):1103-15.
PMID: 22182939
The nonsense-mediated mRNA decay (NMD) pathway was originally discovered by virtue of its ability to rapidly degrade aberrant mRNAs with premature termination codons. More recently, it was shown that NMD...
9.
Raznahan A, Lee Y, Long R, Greenstein D, Clasen L, Addington A, et al.
Mol Psychiatry
. 2010 Jul;
16(9):917-26.
PMID: 20628343
Disrupted-in-schizophrenia-1 (DISC1), contains two common non-synonymous single-nucleotide polymorphisms (SNPs)--Leu607Phe and Ser704Cys--that modulate (i) facets of DISC1 molecular functioning important for cortical development, (ii) fronto-temporal cortical anatomy in adults and (iii)...
10.
Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia
Piton A, Gauthier J, Hamdan F, Lafreniere R, Yang Y, Henrion E, et al.
Mol Psychiatry
. 2010 May;
16(8):867-80.
PMID: 20479760
Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the hypothesis...