J L Meinkoth
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Explore the profile of J L Meinkoth including associated specialties, affiliations and a list of published articles.
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41
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1343
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Recent Articles
1.
Cheng G, Meinkoth J
Oncogene
. 2001 Nov;
20(50):7334-41.
PMID: 11704863
Ras mutations occur at high frequency in thyroid cancer. In vitro, the effects of Ras in thyroid cells are pleiotropic in that expression of activated Ras has been reported to...
2.
Tsygankova O, Saavedra A, Rebhun J, Quilliam L, Meinkoth J
Mol Cell Biol
. 2001 Mar;
21(6):1921-9.
PMID: 11238928
Originally identified as an antagonist of Ras action, Rap1 exhibits many Ras-independent effects, including a role in signaling pathways initiated by cyclic AMP (cAMP). Since cAMP is a critical mediator...
3.
Tsygankova O, Kupperman E, Wen W, Meinkoth J
Oncogene
. 2000 Aug;
19(32):3609-15.
PMID: 10951566
In addition to protein kinase A (PKA), cAMP regulates the activity of cAMP-gated channels and Rap1-specific guanine nucleotide exchange factors. We tested the hypothesis that the targets of cAMP might...
4.
Hsu M, Andl T, Li G, Meinkoth J, Herlyn M
J Cell Sci
. 2000 Apr;
113 ( Pt 9):1535-42.
PMID: 10751145
Reduced gap junction activity has long been implicated in tumorigenesis. To elucidate the potential role of intercellular communication in melanoma development, we examined gap junctional capability of melanocytic cells from...
5.
Cass L, Meinkoth J
Oncogene
. 2000 Mar;
19(7):924-32.
PMID: 10702801
Hormones are specialized mitogens that stimulate proliferation in their differentiated target cells. Thyrotropin (TSH), the physiologic regulator of thyroid cells, stimulates cAMP-mediated proliferation and thyroid-specific gene expression. The mitogenic effects...
6.
Saavedra A, Cass L, Prendergast G, Meinkoth J
Endocrinology
. 2000 Jan;
141(2):606-14.
PMID: 10650941
TSH stimulates proliferation and maintains differentiated function in thyroid follicular cells. The mitogenic activity and the stimulatory effects of TSH on thyroid-specific gene expression are impaired by interferon-gamma (IFNgamma); however,...
7.
Atypical protein kinase C-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells
Fernandez N, Caloca M, Prendergast G, Meinkoth J, Kazanietz M
Endocrinology
. 1999 Dec;
141(1):146-52.
PMID: 10614633
Several reports have indicated that protein kinase C (PKC) is an important regulator of proliferation in thyroid cells. Unlike TSH, the mitogenic effects of phorbol esters are accompanied by de-differentiation....
8.
Cass L, Summers S, Prendergast G, Backer J, Birnbaum M, Meinkoth J
Mol Cell Biol
. 1999 Aug;
19(9):5882-91.
PMID: 10454535
The effects of cyclic AMP (cAMP) on cell proliferation are cell type specific. Although the growth-inhibitory effects of cAMP have been well studied, much less is known regarding how cAMP...
9.
Kunapuli P, Lawson J, Rokach J, Meinkoth J, FitzGerald G
J Biol Chem
. 1998 Aug;
273(35):22442-52.
PMID: 9712868
Prostaglandin receptors may be activated by their cognate ligand or by free radical catalyzed isoprostanes, products of arachidonic acid peroxidation. For example, prostaglandin F2alpha (PGF2alpha) causes hypertrophy of neonatal rat...
10.
Miller M, Rioux L, Prendergast G, Cannon S, White M, Meinkoth J
Mol Cell Biol
. 1998 Jun;
18(7):3718-26.
PMID: 9632754
Ras mutants with the ability to interact with different effectors have played a critical role in the identification of Ras-dependent signaling pathways. We used two mutants, RasS35 and RasG37, which...