J L Kirkland
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Explore the profile of J L Kirkland including associated specialties, affiliations and a list of published articles.
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111
Citations
1250
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Recent Articles
1.
Lin Y, Postma D, Steeneken L, Melo Dos Santos L, Kirkland J, Espindola-Netto J, et al.
Aging Cell
. 2023 Nov;
22(12):e14011.
PMID: 37969056
Accurate biomarkers for predicting COVID-19 severity have remained an unmet need due to an incomplete understanding of virus pathogenesis and heterogeneity among patients. Cellular senescence and its pro-inflammatory phenotype are...
2.
Gonzales M, Garbarino V, Marques Zilli E, Petersen R, Kirkland J, Tchkonia T, et al.
J Prev Alzheimers Dis
. 2022 Jan;
9(1):22-29.
PMID: 35098970
Preclinical studies indicate an age-associated accumulation of senescent cells across multiple organ systems. Emerging evidence suggests that tau protein accumulation, which closely correlates with cognitive decline in Alzheimer's disease and...
3.
Kirkland J, Tchkonia T
J Intern Med
. 2020 Jul;
288(5):518-536.
PMID: 32686219
Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach. SC accumulate with...
4.
Muscedere J, Kim P, Afilalo J, Balion C, Baracos V, Bowdish D, et al.
J Frailty Aging
. 2019 Jun;
8(3):106-116.
PMID: 31237310
The Canadian Frailty Network (CFN), a pan-Canadian not-for-profit organization funded by the Government of Canada through the Networks of Centres of Excellence Program, is dedicated to improving the care of...
5.
Salah H, Fury W, Gromada J, Bai Y, Tchkonia T, Kirkland J, et al.
Acta Physiol (Oxf)
. 2017 Oct;
222(3).
PMID: 29032602
Aim: Muscle wasting is one of the factors most strongly predicting mortality and morbidity in critically ill intensive care unit (ICU). This muscle wasting affects both limb and respiratory muscles,...
6.
Singh M, Jensen M, Lerman A, Kushwaha S, Rihal C, Gersh B, et al.
J Frailty Aging
. 2016 Nov;
5(4):204-207.
PMID: 27883166
Rapamycin, an mTOR inhibitor affects senescence through suppression of senescence-associated secretory phenotype (SASP). We studied the safety and feasibility of low-dose rapamycin and its effect on SASP and frailty in...
7.
Niedernhofer L, Kirkland J, Ladiges W
Ageing Res Rev
. 2016 Oct;
35:241-249.
PMID: 27721062
The first clinical trial aimed at targeting fundamental processes of aging will soon be launched (TAME: Targeting Aging with Metformin). In its wake is a robust pipeline of therapeutic interventions...
8.
Santosa S, Swain J, Tchkonia T, Kirkland J, Jensen M
Int J Obes (Lond)
. 2014 Oct;
39(5):874-6.
PMID: 25319743
Subcutaneous adipose tissue can be obtained for research during an elective, clinically indicated operation by standard surgical excision approaches and by needle aspiration in pure research settings. Whether measurements of...
9.
Millen B, Silliman R, Copenhafer D, Ewart C, Ritchie C, Quatromoni P, et al.
J Nutr Health Aging
. 2001 Dec;
5(4):269-77.
PMID: 11753494
Purpose: To establish the prevalence of nutritional problems and their related socio-demographic and health-related risk factors in the homebound elderly population. Methods: Subjects included 239 men and women, ages 65...
10.
Kirkland J
N Engl J Med
. 2001 Sep;
345(10):771; author reply 771-2.
PMID: 11547759
No abstract available.