J J Kim Wright
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Explore the profile of J J Kim Wright including associated specialties, affiliations and a list of published articles.
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5
Citations
99
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Recent Articles
1.
Pennell A, Aggen J, Sen S, Chen W, Xu Y, Sullivan E, et al.
Bioorg Med Chem Lett
. 2013 Feb;
23(5):1228-31.
PMID: 23374868
A novel series of CCR1 antagonists based on the 1-(4-phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanone scaffold was identified by screening a compound library utilizing CCR1-expressing human THP-1 cells. SAR studies led to the discovery of...
2.
Walters M, Wang Y, Lai N, Baumgart T, Zhao B, Dairaghi D, et al.
J Pharmacol Exp Ther
. 2010 Jul;
335(1):61-9.
PMID: 20660125
The chemokine system represents a diverse group of G protein-coupled receptors responsible for orchestrating cell recruitment under both homeostatic and inflammatory conditions. Chemokine receptor 9 (CCR9) is a chemokine receptor...
3.
Meanwell N, Wallace O, Wang H, Deshpande M, Pearce B, Trehan A, et al.
Bioorg Med Chem Lett
. 2009 Jul;
19(17):5136-9.
PMID: 19632112
1-(4-Benzoylpiperazin-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione (1a) has been characterized as an inhibitor of HIV-1 attachment that interferes with the interaction of viral gp120 with the host cell receptor CD4. In previous studies, the effect...
4.
Meanwell N, Wallace O, Fang H, Wang H, Deshpande M, Wang T, et al.
Bioorg Med Chem Lett
. 2009 Mar;
19(7):1977-81.
PMID: 19251416
The effects of introducing simple halogen, alkyl, and alkoxy substituents to the 4, 5, 6 and 7 positions of 1-(4-benzoylpiperazin-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione, an inhibitor of the interaction between HIV gp120 and host...
5.
Yu K, Sin N, Civiello R, Wang X, Combrink K, Gulgeze H, et al.
Bioorg Med Chem Lett
. 2006 Dec;
17(4):895-901.
PMID: 17169560
A series of benzimidazole-based inhibitors of respiratory syncytial virus (RSV) fusion were optimized for antiviral potency, membrane permeability and metabolic stability in human liver microsomes. 1-Cyclopropyl-1,3-dihydro-3-[[1-(4-hydroxybutyl)-1H-benzimidazol-2-yl]methyl]-2H-imidazo[4,5-c]pyridin-2-one (6m, BMS-433771) was identified...