J J BRUNO
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Explore the profile of J J BRUNO including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
58
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Recent Articles
1.
BRUNO J
N Engl J Med
. 1997 Aug;
337(6):422; author reply 423-4.
PMID: 9244845
No abstract available.
2.
Martinez G, Walker K, Hirschfeld D, BRUNO J, Yang D, MALONEY P
J Med Chem
. 1992 Feb;
35(4):620-8.
PMID: 1311763
A series of 1H-imidazol-1-yl- and 3-pyridyl-substituted 3,4-dihydroquinolin-2(1H)-ones was designed and synthesized as combined inhibitors of thromboxane (TXA2) synthase and cAMP phosphodiesterase (PDE) in human blood platelets. A number of structures,...
3.
Alvarez R, Eglen R, Chang L, BRUNO J, Artis D, Kluge A, et al.
Prostaglandins
. 1991 Aug;
42(2):105-19.
PMID: 1775633
RS-93427, a novel analog of prostacyclin, increased adenylate cyclase activity in human platelet membranes (EC50 = 42 nM) to approximately the same maximum level as that produced by prostacyclin (EC50...
4.
Johnson L, BRUNO J, Allely M, Eglen R, Chang K, Yang D, et al.
Arzneimittelforschung
. 1989 Nov;
39(11):1443-8.
PMID: 2515862
The effects of enprostil (+/-)-7-[(1R*,2R*,3R*)-3-hydroxy-2-[(E)-(3R*)-3-hydroxy-4-phenoxy-1- butenyl]-5-oxocyclopentyl]-4,5-heptadienoate) were studied on cardiovascular and respiratory parameters in the dog and on hematologic parameters in the rat, monkey, and human. Anesthetized dogs were instrumented...
5.
Venuti M, Alvarez R, BRUNO J, Strosberg A, Gu L, Chiang H, et al.
J Med Chem
. 1988 Nov;
31(11):2145-52.
PMID: 2846840
The cyclic AMP phosphodiesterase (cAMP PDE) inhibitor and cardiotonic agent lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)oxy]butyramide, RS-82856, 1) and its acid and base addition salts were found to be insufficiently soluble in formulations...
6.
Venuti M, Stephenson R, Alvarez R, BRUNO J, Strosberg A
J Med Chem
. 1988 Nov;
31(11):2136-45.
PMID: 2846839
Hybridization of structural elements of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline ring system common to the cyclic AMP (cAMP) phosphodiesterase (PDE) inhibitors lixazinone (RS-82856, 1) and anagrelide (3) with complementary features of other PDE inhibitor...
7.
Venuti M, Jones G, Alvarez R, BRUNO J
J Med Chem
. 1987 Feb;
30(2):303-18.
PMID: 3027339
A series of analogues of the cyclic AMP phosphodiesterase (PDE) inhibitor N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)oxy]butyramide (RS-82856, 1) was prepared by systematic variation of the side-chain substituent, length, position, connecting atom, and the...
8.
Jones G, Venuti M, Alvarez R, BRUNO J, Berks A, Prince A
J Med Chem
. 1987 Feb;
30(2):295-303.
PMID: 3027338
Evaluation of a series of lactam heterocyclic analogues of cilostamide (2) as inhibitors of cyclic AMP phosphodiesterase derived from both human platelets and rat heart in comparison with their corresponding...
9.
Strosberg A, Johnson L, Montgomery W, Lee C, Alvarez R, BRUNO J, et al.
Proc West Pharmacol Soc
. 1987 Jan;
30:5-10.
PMID: 3628319
No abstract available.
10.
Knight D, Chapman A, Navre M, Drinkwater L, BRUNO J, Ringold G
Mol Endocrinol
. 1987 Jan;
1(1):36-43.
PMID: 3454870
The stable adipogenic cell line TA1, spontaneously differentiates into mature adipocytes after several days at confluence. Glucocorticoids (e.g. dexamethasone) accelerate the onset of differentiation by precociously activating the transcription of...