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J J BRUNO

Explore the profile of J J BRUNO including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 58
Followers 0
Related Specialties
Chemistry
Pharmacology
Molecular Biology
Top 10 Co-Authors
R Alvarez
M C Venuti
A M Strosberg
G H Jones
L F Chang
A F Kluge
R M Eglen
D Yang
K Chang
L Johnson
Published In
J Med Chem
Prostaglandins
Proc Natl Acad Sci U S A
Arzneimittelforschung
Proc West Pharmacol Soc
Affiliations
Soon will be listed here.
Recent Articles
11.
A potent and selective inhibitor of cyclic AMP phosphodiesterase with potential cardiotonic and antithrombotic properties
Alvarez R, Banerjee G, BRUNO J, Jones G, Littschwager K, Strosberg A, et al.
Mol Pharmacol . 1986 Jun; 29(6):554-60. PMID: 3012320
Some biochemical and pharmacological properties of a novel, potent inhibitor of cyclic AMP phosphodiesterase, N-cyclohexyl-N-methyl-4-(7-oxy-1,2,3,5-tetrahydroimidazo[2,1-b] quinazolin-2-one) butyramide (RS-82856), were investigated. RS-82856 selectively inhibits the high affinity form of cyclic AMP...
12.
Synthesis and platelet aggregation inhibition activity of a series of enantiomeric bicyclo[3.2.0]heptane-6-oximinoacetic acids (1)
Kertesz D, Kluge A, Kuenzler P, Li T, Marx M, BRUNO J, et al.
Prostaglandins . 1984 Jun; 27(6):851-63. PMID: 6484210
Opening of racemic epoxide (3) with (3S)- or (3R)-dimethyl-3-(dimethyl-t-butylsilyloxy)oct-1-ynyl aluminum gave two regioisomers, which were separated chromatographically. The separated regioisomers, themselves mixtures of chromatographically inseparable diastereoisomers, were converted into their...
13.
The effect of oral ticlopidine on arachidonic acid products in human platelets
BRUNO J, Chang L, McSpadden M, Yang D
Agents Actions Suppl . 1984 Jan; 15:76-87. PMID: 6435408
No abstract available.
14.
The mechanisms of action of ticlopidine
BRUNO J
Thromb Res Suppl . 1983 Jan; 4:59-67. PMID: 6356466
No abstract available.
15.
Activation of cardiac adenylate cyclase: horminal modification of the magnesium ion requirement
Alvarez R, BRUNO J
Proc Natl Acad Sci U S A . 1977 Jan; 74(1):92-5. PMID: 264697
Histamine and epinephrine stimulate the activity of guinea pig heart adenylate cyclase [ATP pyrophosphate-lyase (cyclizing) EC 4.6.1.1], in part, by decreasing the requirement for Mg2+ as an activator. This effect...
16.
Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation
BRUNO J, Taylor L, Droller M
Nature . 1974 Oct; 251(5477):721-3. PMID: 4427671
No abstract available.
17.
Hydroxyl group catalysis. II. The reactivity of the hydroxyl group of serine. The nucleophilicity of alcohols and the ease of hydrolysis of their acetyl esters as related to their pKa
Bruice T, Fife T, BRUNO J, BRANDON N
Biochemistry . 1962 Jan; 1:7-12. PMID: 13873927
No abstract available.