J Huard
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Explore the profile of J Huard including associated specialties, affiliations and a list of published articles.
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114
Citations
2437
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Recent Articles
1.
Yamaura K, Nelson A, Nishimura H, Rutledge J, Ravuri S, Bahney C, et al.
Osteoarthritis Cartilage
. 2022 Dec;
31(4):435-446.
PMID: 36586717
Objective: The aim of this study is to analyze the latest evidence on the effects of losartan or Ang II receptor antagonists on cartilage repair, with a focus on their...
2.
Huard J, Gueudry J, Leroy J, Joly L, Muraine M
J Fr Ophtalmol
. 2021 Jul;
44(8):1121-1128.
PMID: 34274163
Introduction: A fire at the Lubrizol chemical factory in Rouen on September 26, 2019 generated a huge column of smoke directed northeast toward the city. As the eye might be...
3.
Deng Z, Li Y, Gao X, Lei G, Huard J
Osteoarthritis Cartilage
. 2018 Mar;
26(9):1153-1161.
PMID: 29580979
Degeneration of articular cartilage (AC) tissue is the most common cause of osteoarthritis (OA) and rheumatoid arthritis. Bone morphogenetic proteins (BMPs) play important roles in bone and cartilage formation. This...
4.
Murray I, Gonzalez Z, Baily J, Dobie R, Wallace R, Mackinnon A, et al.
Nat Commun
. 2017 Oct;
8(1):1118.
PMID: 29061963
Mesenchymal cells expressing platelet-derived growth factor receptor beta (PDGFRβ) are known to be important in fibrosis of organs such as the liver and kidney. Here we show that PDGFRβ cells...
5.
Huard J, Mu X, Lu A
Clin Pharmacol Ther
. 2016 Apr;
100(2):142-6.
PMID: 27071500
Progressive muscle weakness and degeneration due to the lack of dystrophin eventually leads to the loss of independent ambulation by the middle of the patient's second decade, and a fatal...
6.
Proto J, Tang Y, Lu A, Chen W, Stahl E, Poddar M, et al.
Cell Death Dis
. 2015 Apr;
6:e1730.
PMID: 25906153
The transcription factor nuclear factor κB (NF-κB)/p65 is the master regulator of inflammation in Duchenne muscular dystrophy (DMD). Disease severity is reduced by NF-κB inhibition in the mdx mouse, a...
7.
Urish K, Deasy B, Huard J
J Microsc
. 2013 Jan;
249(3):206-14.
PMID: 23323688
Robotic, high-throughput microscopy is a powerful tool for small molecule screening and classifying cell phenotype, proteomic and genomic data. An important hurdle in the field is the automated classification and...
8.
Mifune Y, Matsumoto T, Takayama K, Ota S, Li H, Meszaros L, et al.
Osteoarthritis Cartilage
. 2012 Oct;
21(1):175-85.
PMID: 23041435
Objective: Platelet-rich plasma (PRP) is reported to promote collagen synthesis and cell proliferation as well as enhance cartilage repair. Our previous study revealed that the intracapsular injection of muscle derived...
9.
Yang Q, Tang Y, Imbrogno K, Lu A, Proto J, Chen A, et al.
Gene Ther
. 2012 Jan;
19(12):1196-204.
PMID: 22278411
Chronic inflammation, promoted by an upregulated NF-kappa B (NF-κB) pathway, has a key role in Duchenne muscular dystrophy (DMD) patients' pathogenesis. Blocking the NF-κB pathway has been shown to be...
10.
Tang Y, Reay D, Salay M, Mi M, Clemens P, Guttridge D, et al.
Gene Ther
. 2010 Aug;
17(12):1476-83.
PMID: 20720575
The IκB kinase (IKKα, β and the regulatory subunit IKKγ) complex regulates nuclear factor of κB (NF-κB) transcriptional activity, which is upregulated in many chronic inflammatory diseases. NF-κB signaling promotes...