J G Goddard
Overview
Explore the profile of J G Goddard including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
174
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Recent Articles
1.
Foehr M, Tomei L, Goddard J, PEMBERTON P, Bathurst I
Nutr Cancer
. 1999 Dec;
34(2):199-205.
PMID: 10578488
Previous studies have shown that extracts from soy possess potent antiapoptotic activity in in vitro and in vivo models. We recently reported that this antiapoptotic activity can be attributed to...
2.
Erickson J, Wu J, Goddard J, Tigyi G, Kawanishi K, Tomei L, et al.
J Biol Chem
. 1998 Jan;
273(3):1506-10.
PMID: 9430689
We have functionally expressed the human cDNA encoding the putative lysophosphatidic acid (LPA) receptor Edg-2 (Vzg-1) in Saccharomyces cerevisiae in an attempt to determine the agonist specificity of this G-protein-coupled...
3.
Gower J, Ambrose I, Manek S, Bright J, Dobbin P, Hider R, et al.
Agents Actions
. 1993 Sep;
40(1-2):96-105.
PMID: 8147275
The effect of CP130 (a synthetic hexadentate pyridinone iron chelator) on the formation of two markers of lipid peroxidation (TBA-reactive material and Schiff's bases) in rabbit kidneys following a 72...
4.
Cotterill L, Gower J, CLARK P, Fuller B, Thorniley M, Goddard J, et al.
Biochem Pharmacol
. 1993 May;
45(10):1947-51.
PMID: 8512580
Reoxygenation of hypoxic (120 min at 37 degrees) rabbit kidney cortical slices in vitro resulted in a rapid increase in lipid peroxidation and phosphatidylinositol hydrolysis. No changes in phosphatidylinositol breakdown...
5.
Gower J, Lane N, Goddard J, Manek S, Ambrose I, Green C
Biochem Pharmacol
. 1992 Jun;
43(11):2341-8.
PMID: 1610399
Ebselen (PZ51) was tested for its ability to inhibit oxidative membrane damage and improve outcome of rabbit kidneys rendered cold ischaemic for 72 hr. In view of the rapid metabolism...
6.
Goddard J, Gower J, Green C
Free Radic Res Commun
. 1992 Jan;
17(3):177-85.
PMID: 1459490
In the past, antioxidant and chelator studies have implicated a role for iron-dependent oxidative damage in tissues subjected to ischaemia followed by reperfusion. As ferritin is a major source of...
7.
Kontoghiorghes G, Bartlett A, Hoffbrand A, Goddard J, Sheppard L, Barr J, et al.
Br J Haematol
. 1990 Oct;
76(2):295-300.
PMID: 2094333
A long-term clinical trial of 1-15 months has been carried out with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in 13 transfusion-dependent iron-loaded patients. Urinary iron excretion was greatest in patients...
8.
Kontoghiorghes G, Goddard J, Bartlett A, Sheppard L
Clin Pharmacol Ther
. 1990 Sep;
48(3):255-61.
PMID: 2401124
Pharmacokinetic studies have been carried out with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1). HPLC analysis of serum of a normal volunteer and seven transfusional iron loaded patients who ingested a...
9.
Goddard J, Kontoghiorghes G
Clin Chem
. 1990 Jan;
36(1):5-8.
PMID: 2297936
"High-performance" liquid-chromatographic (HPLC) methods have been developed for identifying 1-substituted 2-alkyl-3-hydroxypyrid-4-one iron chelators in serum and urine. Ion pairing with heptane- or octanesulfonic acid in pH 2.0-2.2 phosphate buffer and...
10.
Kontoghiorghes G, Goddard J, Barr J, Nortey P, Sheppard L
Lancet
. 1989 Aug;
2(8660):457-8.
PMID: 2569645
No abstract available.