J F van der Werf
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Explore the profile of J F van der Werf including associated specialties, affiliations and a list of published articles.
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12
Citations
58
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Recent Articles
1.
Bron J, Sterk G, van der Werf J, Timmerman H
Pharm World Sci
. 1995 Jul;
17(4):120-5.
PMID: 7581217
New organic nitrate esters, derived from structurally different (cyclo)aliphatic templates, were synthesized and pharmacologically investigated. Their in vitro vascular smooth muscle relaxing activities and, occasionally, in vivo haemodynamic profiles were...
2.
SWART J, van der Werf J, Wiegman T, Paans A, Vaalburg W, Korf J
J Cereb Blood Flow Metab
. 1990 May;
10(3):297-306.
PMID: 1970341
Equilibrium models are derived and applied to in vivo binding of spiperone in the rat brain. The models express the concentration of the ligand in the striatum and frontal cortex...
3.
van der Werf J, Timmerman H
Trends Pharmacol Sci
. 1989 Apr;
10(4):159-62.
PMID: 2546304
The histamine H3 receptors were initially identified as presynaptic autoreceptors in the brain. However, recent research described here by Jan van der Werf and Hendrik Timmerman demonstrates that H3 receptors...
4.
van der Vliet A, van der Werf J, Bast A, Timmerman H
J Pharm Pharmacol
. 1988 Aug;
40(8):577-9.
PMID: 2466977
The inhibition of histamine release after depolarization of rat cerebral cortex slices by electrical stimulation and mediated by the postulated presynaptic autoreceptor (H3) depends strongly on the conditions of stimulation....
5.
van der Werf J, Bast A, Bijloo G, van der Vliet A, Timmerman H
Eur J Pharmacol
. 1987 Jun;
138(2):199-206.
PMID: 2887437
Slices of rat brain cortex previously loaded with [3H]histamine ([3H]HA) via de novo synthesis from [3H]histidine released tritiated histamine ([3H]HA) Ca2+ dependently in a superfused system. Both electrical field stimulation...
6.
van der Werf J, Bijloo G, van der Vliet A, Bast A, Timmerman H
Agents Actions
. 1987 Apr;
20(3-4):239-43.
PMID: 2440278
The release of the putative neurotransmitter histamine (HA) from rat brain cortex slices is under negative feedback control by an HA autoreceptor. This autoreceptor has been postulated to belong to...
7.
van der Werf J, Sebens J, Korf J
Life Sci
. 1986 Jul;
39(2):155-60.
PMID: 3724366
Specific tracer and maximal specific binding (Bmax) were determined in rat brain regions from radioactivity accumulation after intravenous administration of 3H N-n-propylnorapomorphine (NPA) or 3H spiperone at various specific activities....
8.
Korf J, Sebens J, Flentge F, van der Werf J
J Neurochem
. 1985 Jan;
44(1):314-8.
PMID: 3964835
In an attempt to quantify the interactions between dopaminergic and cholinergic processes, the consequences of complete or partial activation (with N-n-propylnorapomorphine) or blockade (with spiperone) of dopamine receptors for the...
9.
van der Werf J, van het Schip F, Sebens J, Korf J
Eur J Pharmacol
. 1984 Jul;
102(3-4):387-99.
PMID: 6436037
The potential of in vivo spiperone binding as a tool for the detection and quantitative analysis of striatal dopamine (DA) receptor alterations was studied in rat brain lesioned in several...
10.
van der Werf J, Sebens J, Korf J
Eur J Pharmacol
. 1984 Jul;
102(2):251-9.
PMID: 6434329
The neuronal localization of in vivo N-n-propylnorapomorphine (NPA) binding in the rat striatum was studied using 3 types of lesions. Striatal dopamine (DA) receptor densities (Bmax) were estimated from the...