J F Mercer
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Explore the profile of J F Mercer including associated specialties, affiliations and a list of published articles.
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89
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1680
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Recent Articles
1.
Strausak D, Mercer J, Dieter H, Stremmel W, Multhaup G
Brain Res Bull
. 2001 Jul;
55(2):175-85.
PMID: 11470313
Copper is an essential element for the activity of a number of physiologically important enzymes. Enzyme-related malfunctions may contribute to severe neurological symptoms and neurological diseases: copper is a component...
2.
Lockhart P, Mercer J
Eur J Cell Biol
. 2001 Jul;
80(5):349-57.
PMID: 11432725
In this study we investigated the function of the sheep orthologue of ATP7B (sATP7B), the protein affected in the human copper toxicosis disorder Wilson disease. Two forms of sATP7B are...
3.
Bissig K, La Fontaine S, Mercer J, Solioz M
Biol Chem
. 2001 Jun;
382(4):711-4.
PMID: 11405236
Menkes disease is an X-linked disorder of copper metabolism that is usually fatal. The affected gene has recently been cloned and encodes one of the two human copper ATPases. If...
4.
Mercer J
Trends Mol Med
. 2001 Apr;
7(2):64-9.
PMID: 11286757
Copper (Cu) is a potentially toxic yet essential element. MENKES DISEASE, a copper deficiency disorder, and WILSON DISEASE, a copper toxicosis condition, are two human genetic disorders, caused by mutations...
5.
Voskoboinik I, Greenough M, La Fontaine S, Mercer J, Camakaris J
Biochem Biophys Res Commun
. 2001 Mar;
281(4):966-70.
PMID: 11237756
The Wilson protein (WND; ATP7B) is an essential component of copper homeostasis. Mutations in the ATP7B gene result in Wilson disease, which is characterised by hepatotoxicity and neurological disturbances. In...
6.
La Fontaine S, Theophilos M, Firth S, Gould R, Parton R, Mercer J
Hum Mol Genet
. 2001 Feb;
10(4):361-70.
PMID: 11157799
Wilson disease is an autosomal recessive copper transport disorder resulting from defective biliary excretion of copper and subsequent hepatic copper accumulation and liver failure if not treated. The disease is...
7.
Allen K, Reyes R, Demmler K, Mercer J, Williamson R, Whitehead R
J Gastroenterol Hepatol
. 2000 Dec;
15(11):1325-32.
PMID: 11129229
Background And Aims: The use of hepatocytes for gene therapy is limited by the difficulty of maintaining and altering primary liver cells in culture. A conditionally immortalized mouse hepatocyte cell...
8.
Petris M, Strausak D, Mercer J
Hum Mol Genet
. 2000 Nov;
9(19):2845-51.
PMID: 11092760
Menkes disease is an X-linked recessive copper deficiency disorder caused by mutations in the ATP7A (MNK) gene. The MNK gene encodes a copper-transporting P-type ATPase, MNK, which is localized predominantly...
9.
Michalczyk A, Rieger J, Allen K, Mercer J, Ackland M
Biochem J
. 2000 Nov;
352 Pt 2:565-71.
PMID: 11085952
Toxic milk (tx) is a copper disorder of mice that causes a hepatic accumulation of copper similar to that seen in patients with Wilson disease. Both disorders are caused by...
10.
Lockhart P, Mercer J
Biochim Biophys Acta
. 2000 Apr;
1490(1-2):11-20.
PMID: 10786613
A clone encoding the putative copper chaperone protein Sheep Atx1 Homologue (SAH) was isolated from a sheep liver cDNA library. The 466-bp cDNA encoded a predicted protein of 68 amino...