J F Brunsting
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Explore the profile of J F Brunsting including associated specialties, affiliations and a list of published articles.
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16
Citations
308
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Recent Articles
1.
Setroikromo R, Wierenga P, van Waarde M, Brunsting J, Vellenga E, Kampinga H
Cell Stress Chaperones
. 2008 Jan;
12(4):320-30.
PMID: 18229451
A major problem in autologous stem cell transplantation is the occurrence of relapse by residual neoplastic cells from the graft. The selective toxicity of hyperthermia toward malignant hematopoietic progenitors compared...
2.
Nollen E, Salomons F, Brunsting J, Van Der Want J, Sibon O, Kampinga H
Proc Natl Acad Sci U S A
. 2001 Sep;
98(21):12038-43.
PMID: 11572931
Molecular chaperones are involved in the protection of cells against protein damage through their ability to hold, disaggregate, and refold damaged proteins or their ability to facilitate degradation of damaged...
3.
Sakkers R, Brunsting J, Filon A, Kampinga H, Konings A, Mullenders L
Int J Radiat Biol
. 2001 Feb;
75(7):875-83.
PMID: 10489899
Purpose: Exposure of human cells to heat leads to denaturation and aggregation of proteins. Within the nucleus, it has been suggested that protein aggregation is linked to the selective inhibition...
4.
Nollen E, Kabakov A, Brunsting J, Kanon B, Hohfeld J, Kampinga H
J Biol Chem
. 2000 Nov;
276(7):4677-82.
PMID: 11076956
The chaperone activity of Hsp70 is influenced by the activities of both positive and negative regulatory proteins. In this study, we provide first time evidence for the stimulating effect of...
5.
Nollen E, Brunsting J, Song J, Kampinga H, Morimoto R
Mol Cell Biol
. 2000 Jan;
20(3):1083-8.
PMID: 10629065
Studies on the Hsp70 chaperone machine in eukaryotes have shown that Hsp70 and Hsp40/Hdj1 family proteins are sufficient to prevent protein misfolding and aggregation and to promote refolding of denatured...
6.
Nollen E, Brunsting J, Roelofsen H, Weber L, Kampinga H
Mol Cell Biol
. 1999 Feb;
19(3):2069-79.
PMID: 10022894
Heat shock protein 70 (Hsp70) is thought to play a critical role in the thermotolerance of mammalian cells, presumably due to its chaperone activity. We examined the chaperone activity and...
7.
Resistance to heat radiosensitization and protein damage in thermotolerant and thermoresistant cells
Kampinga H, Konings A, Evers A, Brunsting J, Misfud N, Anderson R
Int J Radiat Biol
. 1997 Mar;
71(3):315-26.
PMID: 9134022
Recently, randomized phase III trials have indicated that hyperthermia combined with radiation leads to significantly better tumour control of certain malignancies than does radio-therapy alone. Yet, the full capacity of...
8.
Woudstra E, Roesink J, Rosemann M, Brunsting J, Driessen C, Orta T, et al.
Int J Radiat Biol
. 1996 Dec;
70(6):693-703.
PMID: 8980667
The role of variation in susceptibility to DNA damage induction was studied as a determinant for cellular radiosensitivity. Comparison of the radiosensitive HX142 and radioresistant RT112 cell lines previously revealed...
9.
Woudstra E, Brunsting J, Roesink J, Konings A, Kampinga H
Mutat Res
. 1996 Jan;
362(1):51-9.
PMID: 8538648
Three human tumour cell lines (HX142, RT112 and MGH-U1) with different radiosensitivities were tested for differences in the rate and/or extent of DNA unwinding in alkali as well as for...
10.
Stege G, Brunsting J, Kampinga H, Konings A
J Cell Physiol
. 1995 Sep;
164(3):579-86.
PMID: 7650065
Heat-induced nuclear protein aggregation and subsequent disaggregation were measured in nonpreheated and preheated (thermotolerant) HeLa S3 cells. The effect of thermotolerance on the formation of and recovery from heat-induced nuclear...