J E Patanella
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Explore the profile of J E Patanella including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
11
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Recent Articles
1.
Walsh J, Patanella J, Halm K, Facchine K
Drug Metab Dispos
. 1995 Aug;
23(8):869-74.
PMID: 7493555
The use of precision-cut liver slices constitutes a new in vitro metabolism technique for the study of coupled phase I and phase II biotransformations. This technique has the advantage of...
2.
Patanella J, Walsh J
Drug Metab Dispos
. 1992 Nov;
20(6):912-9.
PMID: 1362946
Previous metabolism studies of (-)-cis-carbovir (1'R-cis-2-amino-1,9-dihydro-9-[4'S-hydroxymethyl-2-cyclopenten-1- yl]-6H- purin-6-one), an antiviral agent, have shown that the major route of metabolism of carbovir in the rat is oxidation of the methylene hydroxyl...
3.
Patanella J, Walsh J, Unger S, Miwa G, Parry P, Daniel M, et al.
Drug Metab Dispos
. 1990 Nov;
18(6):1092-5.
PMID: 1981518
No abstract available.
4.
Walsh J, Patanella J, Unger S, Brouwer K, Miwa G
Drug Metab Dispos
. 1990 Nov;
18(6):1084-91.
PMID: 1981517
The metabolism and disposition of carbovir [(1R-cis)-2-amino 1,9-(4-(hydroxymethyl)-2-cyclopenten-1-yl)-6H-purin-6-one], an antiviral agent, was examined in rats using an isolated perfused liver, and in vivo following iv and po administration at two...
5.
Brouwer K, St Claire R, Lagarde J, Patanella J, Walsh J, Miwa G
Drug Metab Dispos
. 1990 Nov;
18(6):1078-83.
PMID: 1981516
This study evaluated the pharmacokinetics and bioavailability of (-)-carbovir in rats following iv and po administration at doses of 10 to 120 mg/kg. The systemic clearance decreased 5-fold as the...
6.
FENG P, Wilson A, McClanahan R, Patanella J, Wratten S
Drug Metab Dispos
. 1990 May;
18(3):373-7.
PMID: 1974202
The metabolism of alachlor was studied using in vitro incubations with microsomal fractions prepared from liver and nasal turbinates of rats and mice. Specifically, the transformation of alachlor to 3,5-diethylbenzoquinone-4-imine...
7.
Breaux E, Patanella J, Sanders E, Fujiwara H
Biomed Environ Mass Spectrom
. 1988 Feb;
15(3):123-8.
PMID: 3365488
A new mass spectral method has been developed and used to identify biologically important thiols. This method is based upon the use of C-14 labeled N-para-bromophenylmaleimide (BPM) to selectively derivatize...