J E Heckman
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Explore the profile of J E Heckman including associated specialties, affiliations and a list of published articles.
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23
Citations
618
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Recent Articles
1.
Jay R, Heckman J, Hinshaw L, Best S, Lubner M, Jarrard D, et al.
Urol Oncol
. 2017 Feb;
35(3):119.
PMID: 28159492
Purpose: Percutaneous biopsy obtained from a single location is prone to sampling error in large heterogeneous renal masses, leading to nondiagnostic results or failure to detect poor prognostic features. We...
2.
Iams K, Heckman J, Sinclair J
Plant Mol Biol
. 2013 Dec;
4(4):225-32.
PMID: 24310839
Unfractionated tRNA, isolated from maize mitochondria, has been specifically labeled at the -CCA end and used to recover a tRNA gene-bearing fragment from a clone bank of maize mitochondrial DNA....
3.
Pinard R, Hampel K, Heckman J, Lambert D, Chan P, Major F, et al.
EMBO J
. 2001 Nov;
20(22):6434-42.
PMID: 11707414
The catalytic determinants for the cleavage and ligation reactions mediated by the hairpin ribozyme are integral to the polyribonucleotide chain. We describe experiments that place G8, a critical guanosine, at...
4.
Pinard R, Lambert D, Heckman J, Esteban J, Gundlach 4th C, Hampel K, et al.
J Mol Biol
. 2001 Mar;
307(1):51-65.
PMID: 11243803
The two domains of the hairpin ribozyme-substrate complex, usually depicted as straight structural elements, must interact with one another in order to form an active conformation. Little is known about...
5.
Pinard R, Lambert D, Walter N, Heckman J, Major F, Burke J
Biochemistry
. 1999 Dec;
38(49):16035-9.
PMID: 10587425
To form a catalytically active complex, the essential nucleotides of the hairpin ribozyme, embedded within the internal loops of the two domains, must interact with one another. Little is known...
6.
Pinard R, Heckman J, Burke J
J Mol Biol
. 1999 Mar;
287(2):239-51.
PMID: 10080888
The hairpin ribozyme-substrate complex contains two independently folding domains that interact with one another to form a catalytic complex. However, little is known about the key structural elements involved in...
7.
Yu Q, Pecchia D, Kingsley S, Heckman J, Burke J
J Biol Chem
. 1998 Aug;
273(36):23524-33.
PMID: 9722591
Combinatorial libraries of hairpin ribozymes representing all possible cleavage specificities (>10(5)) were used to evaluate all ribozyme cleavage sites within a large (4.2-kilobase) and highly structured viral mRNA, the 26...
8.
Esteban J, Walter N, Kotzorek G, Heckman J, Burke J
Proc Natl Acad Sci U S A
. 1998 May;
95(11):6091-6.
PMID: 9600922
The RNA cleavage reaction catalyzed by the hairpin ribozyme shows biphasic kinetics, and chase experiments show that the slow phase of the reaction results from reversible substrate binding to an...
9.
Butcher S, Heckman J, Burke J
J Biol Chem
. 1995 Dec;
270(50):29648-51.
PMID: 8530348
The hairpin ribozyme is a 50-nucleotide RNA enzyme of unknown three-dimensional structure. Here, we, demonstrate that interdomain interactions are required for catalytic function by reconstitution of activity following separation of...
10.
Kreader C, Langer C, Heckman J
J Biol Chem
. 1989 Jan;
264(1):317-27.
PMID: 2521217
We have isolated clones representing at least three nuclear genes for mitochondrial ribosomal proteins from Neurospora crassa by screening a lambda gt11 cDNA library with an antiserum against a mixture...