J E Hearst
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Explore the profile of J E Hearst including associated specialties, affiliations and a list of published articles.
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217
Citations
4457
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Recent Articles
1.
Shapiro D, Maestre M, McClain W, Hull P, Shi Y, Quinby-Hunt M, et al.
Appl Opt
. 2010 Oct;
33(24):5733-44.
PMID: 20935975
The coupled-dipole approximation has been used to model polarized light-scattering data obtained from the sperm of the octopus Eledone cirrhosa. Mueller scattering-matrix elements (which describe how a sample alters the...
2.
Brockstedt D, Bahjat K, Giedlin M, Liu W, Leong M, Luckett W, et al.
Nat Med
. 2005 Jul;
11(8):853-60.
PMID: 16041382
We developed a new class of vaccines, based on killed but metabolically active (KBMA) bacteria, that simultaneously takes advantage of the potency of live vaccines and the safety of killed...
3.
Recombinational and mutagenic repair of psoralen interstrand cross-links in Saccharomyces cerevisiae
Greenberg R, Alberti M, Hearst J, Chua M, Saffran W
J Biol Chem
. 2001 Jun;
276(34):31551-60.
PMID: 11390398
Psoralen photoreacts with DNA to form interstrand cross-links, which can be repaired by both nonmutagenic nucleotide excision repair and recombinational repair pathways and by mutagenic pathways. In the yeast Saccharomyces...
4.
The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions
Eichman B, Mooers B, Alberti M, Hearst J, Ho P
J Mol Biol
. 2001 Apr;
308(1):15-26.
PMID: 11302703
The single-crystal structures are presented for two DNA sequences with the thymine bases covalently cross-linked across the complementary strands by 4'-hydroxymethyl-4,5',8-trimethylpsoralen (HMT). The HMT-adduct of d(CCGCTAGCGG) forms a psoralen-induced Holliday...
5.
Mu D, Bessho T, Nechev L, Chen D, Harris T, Hearst J, et al.
Mol Cell Biol
. 2000 Mar;
20(7):2446-54.
PMID: 10713168
DNA interstrand cross-links are induced by many carcinogens and anticancer drugs. It was previously shown that mammalian DNA excision repair nuclease makes dual incisions 5' to the cross-linked base of...
6.
Truitt R, Johnson B, Hanke C, Talib S, Hearst J
J Immunol
. 1999 Oct;
163(9):5145-56.
PMID: 10528221
Donor leukocyte infusions after allogeneic bone marrow transplantation can provide a curative graft-vs-leukemia (GVL) effect, but there is a significant risk of graft-vs-host (GVH) disease. A simple and effective method...
7.
Alkorta I, Park C, Kong J, Garbisu C, Alberti M, Pon N, et al.
Arch Biochem Biophys
. 1999 Jan;
362(1):123-30.
PMID: 9917336
A 30-kDa DNA topoisomerase has been purified to near homogeneity from the purple nonsulfur photosynthetic bacterium Rhodobacter capsulatus. The enzyme is recognized by an antibody against a 16-mer peptide sequence...
8.
Hearst J, Kauffman L, McClain W
Trends Genet
. 1998 Jun;
14(6):244-7.
PMID: 9635408
The interphase nucleus of the human eukaryotic cell, before DNA replication, contains 46 linear DNA molecules, each of the order of centimeters in length, in a spherical nucleus with a...
9.
Lin L, Cook D, Wiesehahn G, Alfonso R, Behrman B, Cimino G, et al.
Transfusion
. 1997 Apr;
37(4):423-35.
PMID: 9111281
Background: A photochemical treatment process has been developed for the inactivation of viruses and bacteria in platelet concentrates. This process is based on the photochemical reaction of a novel psoralen,...
10.
Armstrong G, Hearst J
FASEB J
. 1996 Feb;
10(2):228-37.
PMID: 8641556
The crucial roles of carotenoids and their metabolites in photooxidative protection and photosynthesis, not to mention nutrition, vision, and cellular differentiation, make them an important and complex class of biological...