J D Sutherland
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Explore the profile of J D Sutherland including associated specialties, affiliations and a list of published articles.
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62
Citations
497
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Recent Articles
1.
Rodriguez M, Egana I, Lopitz-Otsoa F, Aillet F, Lopez-Mato M, Dorronsoro A, et al.
Cell Death Dis
. 2014 Aug;
5:e1399.
PMID: 25165885
Accurate regulation of nuclear factor-κB (NF-κB) activity is crucial to prevent a variety of disorders including immune and inflammatory diseases. Active NF-κB promotes IκBα and A20 expression, important negative regulatory...
2.
Albertsen A, Duffy C, Sutherland J, Monnard P
Astrobiology
. 2014 Jun;
14(6):462-72.
PMID: 24885934
The spontaneous formation of closed bilayer structures from prebiotically plausible amphiphiles is an essential requirement for the emergence of early cells on prebiotic Earth. The sources of amphiphiles could have...
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Day Y, Bacon S, Blackburn J, Sutherland J
Chembiochem
. 2002 Dec;
3(12):1192-9.
PMID: 12465027
Dimeric transcription factors of the NF-kappaB/Rel family are sequence-specific DNA-binding proteins that mediate the inducible expression of immunologically important eukaryotic genes by competing for kappaB sites. The kinetic and thermodynamic...
6.
Speight R, Hart D, Sutherland J, Blackburn J
Chem Biol
. 2001 Oct;
8(10):951-65.
PMID: 11590020
Background: Display technologies which allow peptides or proteins to be physically associated with the encoding DNA are central to procedures which involve screening of protein libraries in vitro for new...
7.
Hart D, Speight R, Sutherland J, Blackburn J
J Mol Biol
. 2001 Jul;
310(3):563-75.
PMID: 11439024
An in vivo screen has been devised for NF-kappaB p50 activity in Escherichia coli exploiting the ability of the mammalian transcription factor to emulate a prokaryotic repressor. Active intracellular p50...
8.
Witke W, Sutherland J, Sharpe A, Arai M, Kwiatkowski D
Proc Natl Acad Sci U S A
. 2001 Mar;
98(7):3832-6.
PMID: 11274401
Profilins are thought to play a central role in the regulation of de novo actin assembly by preventing spontaneous actin polymerization through the binding of actin monomers, and the adding...
9.
Klaus A, Klingensmith 3rd W, Parker S, Stavros A, Sutherland J, Aldrete K
AJR Am J Roentgenol
. 2000 Jun;
174(6):1779-83.
PMID: 10845522
Objective: This study was conducted to assess the relative roles of 99mTc-sestamibi scintimammography and sonography in the evaluation of breast lesions that are indeterminate or suspicious on mammography or clinical...
10.
Sutherland J
Curr Opin Chem Biol
. 2000 May;
4(3):263-9.
PMID: 10826970
Aside from the demonstration that individual molecular traits of enzymes can be evolutionarily optimised, the discovery that several traits can be simultaneously optimised is a major advance. The first observations...