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J D Sipley

Explore the profile of J D Sipley including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 3
Citations 31
Followers 0
Related Specialties
Science
Biochemistry
Co-Authors
D S Alexander
J P Quigley
C W Anderson
D C Ward
K O Hartley
J E Testa
S P Jackson
J C Menninger
Published In
Proc Natl Acad Sci U S A
J Biol Chem
Affiliations
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Recent Articles
1.
Autoactivation of avian urokinase-type plasminogen activator (uPA). A novel mode of initiation of the uPA/plasmin cascade
Alexander D, Sipley J, Quigley J
J Biol Chem . 1998 Apr; 273(13):7457-61. PMID: 9516444
In contrast to mammalian urokinase-type plasminogen activator (uPA), which is produced and maintained in zymogen form, avian uPA is found in the active two-chain form in cultures of normal and...
2.
Introduction of an RRHR motif into chicken urokinase-type plasminogen activator (ch-uPA) confers sensitivity to plasminogen activator inhibitor (PAI)-1 and PAI-2 and allows ch-uPA-mediated extracellular matrix degradation to be controlled by PAI-1
Sipley J, Alexander D, Testa J, Quigley J
Proc Natl Acad Sci U S A . 1997 Apr; 94(7):2933-8. PMID: 9096324
Comparison of the amino acid sequence of the chicken and human urokinase-type plasminogen activators (uPAs) revealed that the putative PAI-binding site found in the variable region 1 (VR1) loop of...
3.
Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8
Sipley J, Menninger J, Hartley K, Ward D, Jackson S, Anderson C
Proc Natl Acad Sci U S A . 1995 Aug; 92(16):7515-9. PMID: 7638222
The DNA-activated serine/threonine protein kinase (DNA-PK) is composed of a large (approximately 460 kDa) catalytic polypeptide (DNA-PKcs) and Ku, a heterodimeric DNA-binding component (p70/p80) that targets DNA-PKcs to DNA. A...