J C Strefford
Overview
Explore the profile of J C Strefford including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
585
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0
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Recent Articles
1.
Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Akylzhanova G, Cox K, et al.
Leukemia
. 2017 Aug;
32(2):364-375.
PMID: 28804121
Somatic hypermutation (SHM) is a pivotal process in adaptive immunity that occurs in the germinal centre and allows B cells to change their primary DNA sequence and diversify their antigen...
2.
Young E, Noerenberg D, Mansouri L, Ljungstrom V, Frick M, Sutton L, et al.
Leukemia
. 2016 Nov;
31(7):1547-1554.
PMID: 27890934
Recurrent mutations within EGR2 were recently reported in advanced-stage chronic lymphocytic leukemia (CLL) patients and associated with a worse outcome. To study their prognostic impact, 2403 CLL patients were examined...
3.
Larrayoz M, Rose-Zerilli M, Kadalayil L, Parker H, Blakemore S, Forster J, et al.
Leukemia
. 2016 Oct;
31(2):510-514.
PMID: 27773930
No abstract available.
4.
Parker H, Rose-Zerilli M, Larrayoz M, Clifford R, Edelmann J, Blakemore S, et al.
Leukemia
. 2016 Jun;
30(11):2179-2186.
PMID: 27282254
Histone methyltransferases (HMTs) are important epigenetic regulators of gene transcription and are disrupted at the genomic level in a spectrum of human tumours including haematological malignancies. Using high-resolution single nucleotide...
5.
Rose-Zerilli M, Gibson J, Wang J, Tapper W, Davis Z, Parker H, et al.
Leukemia
. 2016 Feb;
30(6):1301-10.
PMID: 26847028
The biological features of IGHV-M chronic lymphocytic leukemia responsible for disease progression are still poorly understood. We undertook a longitudinal study close to diagnosis, pre-treatment and post relapse in 13...
6.
Larrayoz M, Blakemore S, Dobson R, Blunt M, Rose-Zerilli M, Walewska R, et al.
Leukemia
. 2015 Oct;
30(2):351-60.
PMID: 26488112
The pro-survival Bcl-2 family member Mcl-1 is expressed in chronic lymphocytic leukaemia (CLL), with high expression correlated with progressive disease. The spliceosome inhibitor spliceostatin A (SSA) is known to regulate...
7.
Strefford J, Kadalayil L, Forster J, Rose-Zerilli M, Parker A, Lin T, et al.
Leukemia
. 2015 Aug;
29(12):2411-4.
PMID: 26256637
No abstract available.
8.
Cellura D, Pickard K, Quaratino S, Parker H, Strefford J, Thomas G, et al.
Mol Cancer Res
. 2015 May;
13(7):1095-1105.
PMID: 25934693
Unlabelled: Transglutaminase-2 (TG2) is a critical cross-linking enzyme in the extracellular matrix (ECM) and tumor microenvironment (TME). Although its expression has been linked to colorectal cancer, its functional role in...
9.
Baliakas P, Hadzidimitriou A, Sutton L, Rossi D, Minga E, Villamor N, et al.
Leukemia
. 2014 Jun;
29(2):329-36.
PMID: 24943832
Through the European Research Initiative on chronic lymphocytic leukemia (CLL) (ERIC), we screened 3490 patients with CLL for mutations within the NOTCH1 (n=3334), SF3B1 (n=2322), TP53 (n=2309), MYD88 (n=1080) and...
10.
Martinez N, Almaraz C, Vaque J, Varela I, Derdak S, Beltran S, et al.
Leukemia
. 2013 Dec;
28(6):1334-40.
PMID: 24296945
Splenic marginal zone lymphoma (SMZL) is a B-cell neoplasm whose molecular pathogenesis remains fundamentally unexplained, requiring more precise diagnostic markers. Previous molecular studies have revealed 7q loss and mutations of...