J C Otto
Overview
Explore the profile of J C Otto including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
521
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Recent Articles
1.
Larsen J, Madeleine P, Sorensen L, Sachau J, Otto J, Baron R, et al.
Eur J Pain
. 2023 Sep;
28(2):335-351.
PMID: 37746845
Background: Facilitatory and inhibitory conditioned pain modulation (CPM) responses are observed in healthy volunteers and chronic pain patients, but the clinical implications for phenotyping are unknown. This study aimed to...
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Bergo M, Leung G, Ambroziak P, Otto J, Casey P, Gomes A, et al.
J Biol Chem
. 2000 Dec;
276(8):5841-5.
PMID: 11121396
After isoprenylation, Ras and other CAAX proteins undergo endoproteolytic processing by Rce1 and methylation of the isoprenylcysteine by Icmt (isoprenylcysteine carboxyl methyltransferase). We reported previously that Rce1-deficient mice died during...
4.
Chen Z, Otto J, Bergo M, Young S, Casey P
J Biol Chem
. 2000 Sep;
275(52):41251-7.
PMID: 11007785
After synthesis in the cytosol, Ras proteins must be targeted to the inner leaflet of the plasma membrane for biological activity. This targeting requires a series of C-terminal posttranslational modifications...
5.
Bergo M, Leung G, Ambroziak P, Otto J, Casey P, Young S
J Biol Chem
. 2000 Apr;
275(23):17605-10.
PMID: 10747846
After isoprenylation and endoproteolytic processing, the Ras proteins are methylated at the carboxyl-terminal isoprenylcysteine. The importance of isoprenylation for targeting of Ras proteins to the plasma membrane is well established,...
6.
Spencer A, Thuresson E, Otto J, Song I, Smith T, Dewitt D, et al.
J Biol Chem
. 1999 Nov;
274(46):32936-42.
PMID: 10551860
Prostaglandin endoperoxide H synthases 1 and 2 (PGHS-1 and -2) are the major targets of nonsteroidal anti-inflammatory drugs. Both isozymes are integral membrane proteins but lack transmembrane domains. X-ray crystallographic...
7.
Kim E, Ambroziak P, Otto J, Taylor B, Ashby M, Shannon K, et al.
J Biol Chem
. 1999 Mar;
274(13):8383-90.
PMID: 10085069
Little is known about the enzyme(s) required for the endoproteolytic processing of mammalian Ras proteins. We identified a mouse gene (designated Rce1) that shares sequence homology with a yeast gene...
8.
Otto J, Kim E, Young S, Casey P
J Biol Chem
. 1999 Mar;
274(13):8379-82.
PMID: 10085068
Proteins containing C-terminal "CAAX" sequence motifs undergo three sequential post-translational processing steps: modification of the cysteine with either a 15-carbon farnesyl or 20-carbon geranylgeranyl isoprenyl lipid, proteolysis of the C-terminal...
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Otto J, Smith W
J Biol Chem
. 1996 Apr;
271(17):9906-10.
PMID: 8626626
Previous studies of the crystal structure of the ovine prostaglandin endoperoxide H synthase-1 (PGHS-1)/S-flurbiprofen complex (Picot, D., Loll, P. J., and Garavito, R. M. (1994) Nature 367, 243-249) suggest that...