J C Hanvey
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Explore the profile of J C Hanvey including associated specialties, affiliations and a list of published articles.
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15
Citations
519
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Recent Articles
1.
Bonham M, Brown S, Boyd A, Brown P, Bruckenstein D, Hanvey J, et al.
Nucleic Acids Res
. 1995 Apr;
23(7):1197-203.
PMID: 7537874
The antisense activity and gene specificity of two classes of oligonucleotides (ONs) were directly compared in a highly controlled assay. One class of ONs has been proposed to act by...
2.
Peffer N, Hanvey J, Bisi J, Thomson S, Hassman C, Noble S, et al.
Proc Natl Acad Sci U S A
. 1993 Nov;
90(22):10648-52.
PMID: 8248156
Polyamide oligomers, termed peptide nucleic acids (PNAs), bind with high affinity to both DNA and RNA and offer both antisense and antigene approaches for regulating gene expression. When a PNA...
3.
Hanvey J, Peffer N, Bisi J, Thomson S, Cadilla R, Josey J, et al.
Science
. 1992 Nov;
258(5087):1481-5.
PMID: 1279811
Peptide nucleic acids (PNAs) are polyamide oligomers that can strand invade duplex DNA, causing displacement of one DNA strand and formation of a D-loop. Binding of either a T10 PNA...
4.
Hanvey J, Williams E, Besterman J
Antisense Res Dev
. 1991 Jan;
1(4):307-17.
PMID: 1821652
Oligonucleotides that form a triple helix with duplex DNA offer a novel way to site specifically regulate gene expression in vivo. Triple helices formed by homopyrimidine oligomers containing both cytosine...
5.
Shimizu M, Hanvey J, Wells R
Biochemistry
. 1990 May;
29(19):4704-13.
PMID: 2372553
A polypurine.polypyrimidine (Pur.Pyr) sequence with a central interruption in a plasmid can adopt multiple non-B-DNA conformations depending on the conditions as revealed by specific chemical probes (OsO4, diethyl pyrocarbonate, and...
6.
Hanvey J, Shimizu M, Wells R
Nucleic Acids Res
. 1990 Jan;
18(1):157-61.
PMID: 2308821
The ability of oligopyrimidines to inhibit, through triple helix formation, the specific protein-DNA interactions of the EcoRI restriction and modification enzymes (EcoRI and MEcoRI) with their recognition sequence (GAATTC) was...
7.
Hanvey J, Shimizu M, Wells R
J Biol Chem
. 1989 Apr;
264(10):5950-6.
PMID: 2647731
The effects of interruptions in the homopurine bias and the G+C content of the homopurine.homopyrimidine (pur.pyr) sequences on intramolecular triplex formation and stability in supercoiled plasmids were evaluated. In addition,...
8.
Shimizu M, Hanvey J, Wells R
J Biol Chem
. 1989 Apr;
264(10):5944-9.
PMID: 2647730
The capacity of four oligopurine.oligopyrimidine (pur.pyr) sequences with different lengths of interruptions in the center [GAA)4(N)n(GAA)4G) (n = 3, 5, 7, and 9) to adopt intramolecular DNA triplexes was evaluated...
9.
The chemistry and biology of unusual DNA structures adopted by oligopurine.oligopyrimidine sequences
Wells R, Collier D, Hanvey J, Shimizu M, WOHLRAB F
FASEB J
. 1988 Nov;
2(14):2939-49.
PMID: 3053307
A family of unusual DNA structures has been discovered in segments with predominantly purines in one strand (pur.pyr sequences). These sequences are overrepresented in eukaryotic DNA and have been mapped...
10.
Hanvey J, Shimizu M, Wells R
Proc Natl Acad Sci U S A
. 1988 Sep;
85(17):6292-6.
PMID: 3413097
A series of inserts with oligopurine.oligopyrimidine mirror repeat sequences was investigated at the base pair level with specific chemical probes (OsO4 and diethylpyrocarbonate) to evaluate the in vitro existence of...