J Bradford Bowzard
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Explore the profile of J Bradford Bowzard including associated specialties, affiliations and a list of published articles.
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13
Citations
304
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Recent Articles
1.
Bowzard J, Ranjan P, Sambhara S
Cell Host Microbe
. 2013 Mar;
13(3):247-9.
PMID: 23498950
It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe,...
2.
East M, Bowzard J, Dacks J, Kahn R
J Biol Chem
. 2012 Sep;
287(47):39538-53.
PMID: 23014990
The human family of ELMO domain-containing proteins (ELMODs) consists of six members and is defined by the presence of the ELMO domain. Within this family are two subclassifications of proteins,...
3.
Davis W, Bowzard J, Sharma S, Wiens M, Ranjan P, Gangappa S, et al.
PLoS One
. 2012 Mar;
7(3):e32661.
PMID: 22438882
Retinoic acid inducible gene-I (RIG-I) is a key regulator of antiviral immunity. RIG-I is generally thought to be activated by ssRNA species containing a 5'-triphosphate (PPP) group or by unphosphorylated...
4.
Gaur P, Ranjan P, Sharma S, Patel J, Bowzard J, Rahman S, et al.
J Biol Chem
. 2012 Mar;
287(18):15109-17.
PMID: 22396546
The influenza virus neuraminidase (NA) protein primarily aids in the release of progeny virions from infected cells. Here, we demonstrate a novel role for NA in enhancing host cell survival...
5.
Bowzard J, Davis W, Jeisy-Scott V, Ranjan P, Gangappa S, Fujita T, et al.
Trends Biochem Sci
. 2011 Apr;
36(6):314-9.
PMID: 21497095
Retinoic-acid-inducible gene-I (RIG-I) is an important component of the innate immune response to many RNA viruses that limits viral replication until adaptive immunity becomes available to clear the infection. Upon...
6.
Chakravarthy K, Bonoiu A, Davis W, Ranjan P, Ding H, Hu R, et al.
Proc Natl Acad Sci U S A
. 2010 May;
107(22):10172-7.
PMID: 20498074
The emergence of the pandemic 2009 H1N1 influenza virus has become a world-wide health concern. As drug resistance appears, a new generation of therapeutic strategies will be required. Here, we...
7.
Ranjan P, Bowzard J, Schwerzmann J, Jeisy-Scott V, Fujita T, Sambhara S
Trends Mol Med
. 2009 Aug;
15(8):359-68.
PMID: 19665430
The innate immune system uses pattern recognition receptors (PRRs) to sense invading microbes and initiate a rapid protective response. PRRs bind and are activated by structural motifs, such as nucleic...
8.
Bowzard J, Ranjan P, Sambhara S, Fujita T
Cytokine Growth Factor Rev
. 2009 Feb;
20(1):1-5.
PMID: 19211297
A critical component of the innate immune response is the presence of germ line-encoded receptors capable of recognizing a wide variety of pathogen-associated molecules. One group of these receptors, the...
9.
Lokhandwala P, Nguyen T, Bowzard J, Craven R
Virology
. 2008 Apr;
376(1):191-8.
PMID: 18433823
The second helix in the C-terminal domain of retroviral capsid (CA) protein functions as the site of dimerization between subunits in capsid assembly and is believed to participate in a...
10.
Bowzard J, Cheng D, Peng J, Kahn R
J Biol Chem
. 2007 Apr;
282(24):17568-80.
PMID: 17452337
Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP binding and hydrolysis, controlled by guanine nucleotide exchange factors and GTPase-activating proteins (GAPs), as essential features of their...