J Anthony Brandon
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Explore the profile of J Anthony Brandon including associated specialties, affiliations and a list of published articles.
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19
Citations
182
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Recent Articles
1.
Miller J, Brandon J, McKinnon L, Sabra H, Lucido C, Gonzalez Murcia J, et al.
bioRxiv
. 2025 Jan;
PMID: 39829933
Background: Synonymous variant () in the Paired Immunoglobulin-like Type 2 Receptor Alpha () gene was previously associated with decreased risk for Alzheimer's disease (AD) in genome-wide association studies, but its...
2.
Shade L, Katsumata Y, Abner E, Aung K, Claas S, Qiao Q, et al.
Nat Genet
. 2024 Oct;
56(11):2407-2421.
PMID: 39379761
Genome-wide association studies (GWAS) have identified >80 Alzheimer's disease and related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in most previous studies belie the complex nature of underlying...
3.
Heberle B, Brandon J, Page M, Nations K, Dikobe K, White B, et al.
Nat Biotechnol
. 2024 May;
PMID: 38778214
Determining whether the RNA isoforms from medically relevant genes have distinct functions could facilitate direct targeting of RNA isoforms for disease treatment. Here, as a step toward this goal for...
4.
Page M, Heberle B, Brandon J, Wadsworth M, Gordon L, Nations K, et al.
bioRxiv
. 2024 Feb;
PMID: 38405825
Even though alternative RNA splicing was discovered nearly 50 years ago (1977), we still understand very little about most isoforms arising from a single gene, including in which tissues they...
5.
Yang H, Howerton B, Brown L, Izumi T, Cheek D, Brandon J, et al.
Cancers (Basel)
. 2023 Dec;
15(24).
PMID: 38136418
Background: Magnetic resonance imaging (MRI) is a non-invasive imaging modality which, in conjunction with biopsies, provide a qualitative assessment of tumor response to treatment. Intravenous injection of contrast agents such...
6.
Heberle B, Brandon J, Page M, Nations K, Dikobe K, White B, et al.
bioRxiv
. 2023 Aug;
PMID: 37609156
Due to alternative splicing, human protein-coding genes average over eight RNA isoforms, resulting in nearly four distinct protein coding sequences per gene. Long-read RNAseq (IsoSeq) enables more accurate quantification of...
7.
Khurana A, Marti F, Powell D, Brandon J, Dugan A, Gedaly R, et al.
Sci Rep
. 2022 Oct;
12(1):17640.
PMID: 36271098
The success of several cell-based therapies and prevalent use of magnetic resonance imaging (MRI) in the clinic has fueled the development of contrast agents for specific cell tracking applications. Safe...
8.
Farmer B, Williams H, Devanney N, Piron M, Nation G, Carter D, et al.
Mol Neurodegener
. 2021 Sep;
16(1):62.
PMID: 34488832
Background: Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer's disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the...
9.
Brandon J, Kraemer M, Vandra J, Halder S, Ubele M, Morris A, et al.
PLoS One
. 2019 Feb;
14(2):e0208099.
PMID: 30730895
Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA). We generated mice with global inducible post-natal inactivation or adipose-specific loss of the Enpp2 gene encoding...
10.
Meier S, Gilad A, Brandon J, Qian C, Gao E, Abisambra J, et al.
Sci Rep
. 2018 Mar;
8(1):4638.
PMID: 29545551
Research into gene therapy for heart failure has gained renewed interest as a result of improved safety and availability of adeno-associated viral vectors (AAV). While magnetic resonance imaging (MRI) is...