J A Weisbach
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Explore the profile of J A Weisbach including associated specialties, affiliations and a list of published articles.
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54
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Recent Articles
11.
PITKIN D, Actor P, BALDINUS J, Post A, Weisbach J
J Antibiot (Tokyo)
. 1978 Apr;
31(4):359-62.
PMID: 26651
A quantitative semi-automated turbidimetric bioassay for cefazaflur, using Streptococcus faecium as the indicator, is described. Assays were run at pH 6.5 approximately 7 for 3.75 hours at 37 degrees C...
12.
Uri J, Actor P, GUARINI J, Phillips L, Pitkin D, DeMarinis R, et al.
J Antibiot (Tokyo)
. 1978 Jan;
31(1):82-91.
PMID: 627526
Three semisynthetic cephamycin antibiotics (7alpha-methoxy-cephalosporins), SK&F 73678, SK&F 83088 (CS-1170) and cefoxitin, have been found to possess favorable biological and chemotherapeutic properties. All three cephamycins are active in vitro against...
13.
Sitrin R, Cooper D, Weisbach J
J Antibiot (Tokyo)
. 1977 Oct;
30(10):836-42.
PMID: 591446
The synthesis of 2-deoxy-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythrohexopyranosyl)-6-O-(3-deoxy-3-methylamino-alpha-D-xylopyranosyl)-D-streptamine (1), an analog of gentamicin A, from diideoxyneamine and methyl 3-methylamino-3-deoxy-beta-D-xylopyranoside is described. The product was characterized by its 13C nmr spectrum and was found to...
14.
Actor P, GUARINI J, URI J, Bartus H, Zajac I, Weisbach J
J Antibiot (Tokyo)
. 1977 Sep;
30(9):730-5.
PMID: 924896
Cefazaflur has a broad-spectrum of in vitro antibacterial activity equal to or greater than that of the commercially-available cephalosporins. In addition, cefazaflur has activity against isolates of Enterobacter, Citrobacter and...
15.
Pitkin D, Actor P, Filan J, White R, Weisbach J
Antimicrob Agents Chemother
. 1977 Aug;
12(2):284-5.
PMID: 20044
A marked loss in potency was observed when cephalothin was incubated for 5 h in human serum at 37 degrees C. Cefazolin was stable under these conditions.
16.
DeMarinis R, Boehm J, Dunn G, Hoover J, Uri J, GUARINI J, et al.
J Med Chem
. 1977 Jan;
20(1):30-5.
PMID: 319233
The synthesis and in vitro and in vivo activities of a series of cephalosporins having side chains derived from 2-[(2,2,2-trifluoroethyl)thio]acetic acid or 2-(cyanomethylthio)acetic acid and with acetoxymethyl or 3-heterocyclic thiomethyl...
17.
DeMarinis R, Uri J, Weisbach J
J Antibiot (Tokyo)
. 1976 Sep;
29(9):973-5.
PMID: 993139
No abstract available.
18.
DeMarinis R, Hoover J, Lam L, Uri J, GUARINI J, Phillips L, et al.
J Med Chem
. 1976 Jun;
19(6):754-9.
PMID: 781242
The synthesis and in vitro and in vivo activities of a series of 7-sulfonylacetamido-3-cephem-4-carboxylic acids with acetoxymethyl or heterocyclic thiomethyl substituents at the 3 position are described. Lengthening the alkyl...
19.
Actor P, PITKIN D, Lucyszyn G, Weisbach J, Bran J
Antimicrob Agents Chemother
. 1976 May;
9(5):800-3.
PMID: 949177
Cefatrizine (SK&F 60771), a new broad-spectrum cephalosporin, was administered in a 0.5-g dose either orally or intramuscularly to volunteers in a crossover study. After oral administration, the average peak serum...
20.
Uri J, Actor P, Phillips L, GUARINI J, Weisbach J
Chemotherapy
. 1976 Jan;
22(5):313-8.
PMID: 780071
The disc sensitivity and minimal inhibitory concentrations (MIC) of cefazolin and cephalothin were compared against a series of Escherichia coli isolates. These data were correlated with the mouse protective doses...