J A Sakoff
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Explore the profile of J A Sakoff including associated specialties, affiliations and a list of published articles.
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13
Citations
116
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Recent Articles
1.
Gilbert J, De Iuliis G, McCluskey A, Sakoff J
Sci Rep
. 2020 Aug;
10(1):13978.
PMID: 32814815
We report that the naphthalimide analogue 2-(2-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (NAP-6) is a highly potent and selective breast cancer targeting molecule. These effects are mediated via the aryl hydrocarbon receptor (AHR) pathway and...
2.
Garg M, Lincz L, Adler K, Scorgie F, Ackland S, Sakoff J
Br J Cancer
. 2012 Sep;
107(9):1525-33.
PMID: 22990653
Background: Identifying various pretreatment factors that predict chemotherapy-induced toxicity in colorectal cancer (CRC) patients undergoing treatment for their disease is crucial to optimising patient care. Methods: Seventy-three patients received adjuvant...
3.
de Bock C, Garg M, Scott N, Sakoff J, Scorgie F, Ackland S, et al.
Pharmacogenomics J
. 2010 Jun;
11(4):307-14.
PMID: 20531375
Two known polymorphisms in the 5' enhancer region (ER) of the thymidylate synthase (TS) gene, a variable number of tandem repeats of a 28 bp sequence (2R/3R) and a further...
4.
Lincz L, Scorgie F, Sakoff J, Fagan K, Ackland S, Enno A
Bone Marrow Transplant
. 2004 Jul;
34(5):439-45.
PMID: 15258557
Haemopoietic regeneration after autologous peripheral blood progenitor cell (PBPC) transplantation can be delayed in some patients despite adequate infusion of CD34(+) cells. This suggests variability in the proliferation potential of...
5.
McCluskey A, Ackland S, Gardiner E, Walkom C, Sakoff J
Anticancer Drug Des
. 2002 Oct;
16(6):291-303.
PMID: 12375882
Recent investigations in our laboratories have highlighted that the inhibition of the serine/threonine protein phosphatases 1 and 2A (PP1 and PP2A) is an excellent target for the development of novel...
6.
McCluskey A, Sakoff J
Mini Rev Med Chem
. 2002 Oct;
1(1):43-55.
PMID: 12369990
Serine/threonine protein phosphatases have long been ignored as potential therapeutic targets for two reasons, one the biochemical significance of these proteins has not been appreciated and two, many natural protein...
7.
McCluskey A, Walkom C, Bowyer M, Ackland S, Gardiner E, Sakoff J
Bioorg Med Chem Lett
. 2001 Oct;
11(22):2941-6.
PMID: 11677131
Cantharidin and its analogues have been of considerable interest as potent inhibitors of the serine/threonine protein phosphatases 1 and 2A (PP1 and PP2A). However, limited modifications to the parent compounds...
8.
Sakoff J, Ackland S
Cancer Chemother Pharmacol
. 2001 Jan;
46(6):477-87.
PMID: 11138461
In this study, the downstream effects of thymidylate synthase (TS) inhibition in L1210 (p53 mutant) and HL60 (p53 null) leukaemia cells were investigated. TS inhibition was induced by the specific...
9.
McCluskey A, Bowyer M, Collins E, Sim ATR , Sakoff J, Baldwin M
Bioorg Med Chem Lett
. 2000 Aug;
10(15):1687-90.
PMID: 10937725
Two series of anhydride modified cantharidin analogues were synthesised and screened for their phosphatase inhibition (PP1 and PP2A) and cytotoxicity in various cancer cell lines (Ovarian A2780, ADDP; Osteosarcoma 143B;...
10.
Sakoff J, Dunstan R, Murdoch R
Mol Reprod Dev
. 1996 May;
44(1):93-102.
PMID: 8722697
Lipid extracts of whole uterine tissue from mice were examined by gas chromatography-mass spectrometry during days 2,3, and 4 pseudopregnancy (day 1 = copulatory plug) and following the artificial induction...