J A Melick
Overview
Explore the profile of J A Melick including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
94
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Recent Articles
1.
Robertson C, Hendrich K, Kochanek P, Jackson E, Melick J, Graham S, et al.
Acta Neurochir Suppl
. 2001 Jul;
76:187-9.
PMID: 11450003
Adenosine is a putative endogenous neuroprotectant. Its action at A1 receptors mitigates excitotoxicity while action at A2 receptors increases cerebral blood flow (CBF). We hypothesized that cerebral injection of the...
2.
Hendrich K, Kochanek P, Melick J, Schiding J, Statler K, Williams D, et al.
Magn Reson Med
. 2001 Jul;
46(1):202-6.
PMID: 11443729
The influence of anesthetic agents on cerebral blood flow (CBF) was tested in normal rats. CBF is quantified with arterial spin-labeled MRI in rats anesthetized with either an opiate (fentanyl),...
3.
Kochanek P, Hendrich K, Robertson C, Williams D, Melick J, Ho C, et al.
Magn Reson Med
. 2001 Apr;
45(5):924-9.
PMID: 11323821
Adenosine analogs such as 2-chloroadenosine are potent cerebrovasodilators. Spin-labeled MRI was used to investigate the spatial distribution, dose-response, and timing of the effect of 2-chloroadenosine on cerebral blood flow (CBF)...
4.
Tang P, Liachenko S, Melick J, Xu Y
Epilepsia
. 1998 Jun;
39(6):577-83.
PMID: 9637598
Purpose: Kainic acid (KA) has long been used in experimental animals to induce status epilepticus (SE). A mechanistic implication of this is the association between excitotoxicity and brain damage during...
5.
Nemoto E, Klementavicius R, Melick J, Yonas H
Anesth Analg
. 1996 Dec;
83(6):1262-7.
PMID: 8942597
In an earlier study on the effect of mild hypothermia (34 degrees C) on the cerebral metabolic rate for oxygen (CMRO2) in rats, we used norepinephrine (NE) to support arterial...
6.
Nemoto E, Klementavicius R, Melick J, Yonas H
J Neurosurg Anesthesiol
. 1996 Jan;
8(1):52-9.
PMID: 8719194
If the efficacy of hypothermia and barbiturates in ameliorating ischemic brain injury lies in reducing the cerebral metabolic rate of oxygen (CMRO2), the greater efficacy of mild hypothermia (34 degrees...
7.
Nemoto E, Klementavicius R, Melick J, Yonas H
Adv Exp Med Biol
. 1994 Jan;
361:469-73.
PMID: 7597971
No abstract available.
8.
Darby J, Nemoto E, Yonas H, Yao L, Melick J, Boston J
J Cereb Blood Flow Metab
. 1993 Sep;
13(5):763-72.
PMID: 8360283
We developed a closed-skull model of freeze injury-induced brain edema, a model classically thought to produce vasogenic edema, and observed the natural course of changes in edema and blood flow...
9.
Chavko M, Nemoto E, Melick J
Mol Chem Neuropathol
. 1993 Jan;
18(1-2):123-31.
PMID: 8466586
The lipid composition of the brain is of great importance to its metabolism and function. Although much research has been done on regional brain lipid composition, studies usually suffer from...
10.
Love J, Nemoto E, Yonas H, Darby J, Melick J
J Neurosurg Anesthesiol
. 1992 Oct;
4(4):257-60.
PMID: 15815474
Stable xenon (Xe) gas, at inspired concentrations above 30%, reportedly increased cerebral blood flow (CBF) in animals and humans. An unpredictable Xe-induced elevation of CBF could result in erroneous CBF...