J A DiDonato
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Explore the profile of J A DiDonato including associated specialties, affiliations and a list of published articles.
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25
Citations
2316
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Recent Articles
1.
Zhu W, Buffa J, Wang Z, Warrier M, Schugar R, Shih D, et al.
J Thromb Haemost
. 2018 Jul;
16(9):1857-1872.
PMID: 29981269
Summary: Background Gut microbes play a critical role in the production of trimethylamine N-oxide (TMAO), an atherogenic metabolite that impacts platelet responsiveness and thrombosis potential. Involving both microbe and host...
2.
DiDonato J
Sci STKE
. 2001 Nov;
2001(97):pe1.
PMID: 11698579
Inhibitor of kappaB kinase alpha (IKK alpha) was originally identified as a component of a multiprotein kinase complex that regulates the activity of the transcription factor nuclear factor-kappaB (NF-kappaB) through...
3.
B lymphocytes and plasma cells express functional E-selectin by constitutive activation of NF-kappaB
Liu L, Xia Y, Yang L, DiDonato J, DiCorleto P, Zhong C, et al.
Biochem Biophys Res Commun
. 2001 Aug;
286(2):281-91.
PMID: 11500034
E-selectin (CD62E), a cell adhesion molecule for most leukocytes, is known to be expressed exclusively on the cytokine-stimulated endothelial cells mainly by inductive activation of NF-kappaB. Using immunohistochemistry and in...
4.
Purcell N, Tang G, Yu C, Mercurio F, DiDonato J, Lin A
Proc Natl Acad Sci U S A
. 2001 Jun;
98(12):6668-73.
PMID: 11381115
The transcription factor NF-kappaB regulates expression of genes that are involved in inflammation, immune response, viral infection, cell survival, and division. However, the role of NF-kappaB in hypertrophic growth of...
5.
Purcell N, Yu C, He D, Xiang J, Paran N, DiDonato J, et al.
Am J Physiol Gastrointest Liver Physiol
. 2001 Mar;
280(4):G669-77.
PMID: 11254493
pX, the hepatitis B virus-encoded transcription coactivator, is involved in viral infection in vivo. pX stimulates the activity of several transcription factors including nuclear factor-kappaB (NF-kappaB), but the mechanism of...
6.
7.
Mogensen T, DiDonato J, Williams B
Mol Cell Biol
. 2000 Jan;
20(4):1278-90.
PMID: 10648614
The interferon (IFN)-inducible double-stranded-RNA (dsRNA)-activated serine-threonine protein kinase (PKR) is a major mediator of the antiviral and antiproliferative activities of IFNs. PKR has been implicated in different stress-induced signaling pathways...
8.
Elewaut D, DiDonato J, Kim J, Truong F, Eckmann L, Kagnoff M
J Immunol
. 1999 Jul;
163(3):1457-66.
PMID: 10415047
Human intestinal epithelial cells up-regulate the expression of an inflammatory gene program in response to infection with a spectrum of different strains of enteroinvasive bacteria. The conserved nature of this...
9.
Chu Z, Shin Y, Yang J, DiDonato J, Ballard D
J Biol Chem
. 1999 May;
274(22):15297-300.
PMID: 10336413
The Tax oncoprotein of human T cell leukemia virus type 1 constitutively activates transcription factor NF-kappaB by a mechanism involving Tax-induced phosphorylation of IkappaBalpha, a labile cytoplasmic inhibitor of NF-kappaB....
10.
Nemoto S, DiDonato J, Lin A
Mol Cell Biol
. 1998 Nov;
18(12):7336-43.
PMID: 9819420
IkappaB kinases (IKKalpha and IKKbeta) are key components of the IKK complex that mediates activation of the transcription factor NF-kappaB in response to extracellular stimuli such as inflammatory cytokines, viral...