Izumi Maezawa
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Explore the profile of Izumi Maezawa including associated specialties, affiliations and a list of published articles.
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67
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2058
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Recent Articles
1.
Zheng J, Hong B, Agus J, Tang X, Guo F, Lebrilla C, et al.
Cell Rep Methods
. 2025 Jan;
5(1):100962.
PMID: 39874947
High-density lipoprotein (HDL) particle diameter distribution is informative in the diagnosis of many conditions, including Alzheimer's disease (AD). However, obtaining an accurate HDL size measurement is challenging. We demonstrated the...
2.
Di Lucente J, Ramsey J, Jin L, Maezawa I
FASEB Bioadv
. 2024 Dec;
6(12):581-596.
PMID: 39650227
Ketotherapeutics is a potential metabolic intervention for mitigating dementias; however, its mechanisms and optimal methods of application are not well understood. Our previous in vitro study showed that β-hydroxybutyrate (BHB),...
3.
Tang X, Schindler R, Lucente J, Oloumi A, Tena J, Harvey D, et al.
Res Sq
. 2024 Nov;
PMID: 39606433
Microglia are the immune cells in the central nervous system (CNS) and become pro-inflammatory/activated in Alzheimer's disease (AD). Cell surface glycosylation plays an important role in immune cells; however, the...
4.
Budamagunta M, Mori H, Silk J, Slez R, Bognar B, Ruiz Mendiola U, et al.
Antioxidants (Basel)
. 2024 Nov;
13(11).
PMID: 39594552
The disorder and heterogeneity of low-molecular-weight amyloid-beta oligomers (AβOs) underlie their participation in multiple modes of cellular dysfunction associated with the etiology of Alzheimer's disease (AD). The lack of specified...
5.
Romo E, Hong B, Patel R, Agus J, Harvey D, Maezawa I, et al.
Front Neurol
. 2024 Jun;
15:1408220.
PMID: 38882697
Introduction: The role of lipopolysaccharide binding protein (LBP), an inflammation marker of bacterial translocation from the gastrointestinal tract, in Alzheimer's disease (AD) is not clearly understood. Methods: In this study...
6.
Shafer C, Di Lucente J, Ruiz Mendiola U, Maezawa I, Jin L, Neumann E
J Am Soc Mass Spectrom
. 2024 Mar;
35(11):2554-2563.
PMID: 38456419
Diet is inextricably linked to human health and biological functionality. Reduced cognitive function among other health issues has been correlated with a western diet (WD) in mouse models, indicating that...
7.
Di Lucente J, Persico G, Zhou Z, Jin L, Ramsey J, Rutkowsky J, et al.
Commun Biol
. 2024 Feb;
7(1):195.
PMID: 38366025
The Ketogenic Diet (KD) improves memory and longevity in aged C57BL/6 mice. We tested 7 months KD vs. control diet (CD) in the mouse Alzheimer's Disease (AD) model APP/PS1. KD...
8.
Jin L, Di Lucente J, Ruiz Mendiola U, Suthprasertporn N, Tomilov A, Cortopassi G, et al.
FASEB J
. 2023 Oct;
37(11):e23261.
PMID: 37878335
Fatty acids are metabolized by β-oxidation within the "mitochondrial ketogenic pathway" (MKP) to generate β-hydroxybutyrate (BHB), a ketone body. BHB can be generated by most cells but largely by hepatocytes...
9.
Munoz Herrera O, Hong B, Ruiz Mendiola U, Maezawa I, Jin L, Lebrilla C, et al.
Int J Mol Sci
. 2023 Jun;
24(12).
PMID: 37373543
Research has found that genes specific to microglia are among the strongest risk factors for Alzheimer's disease (AD) and that microglia are critically involved in the etiology of AD. Thus,...
10.
Tang X, Tena J, Di Lucente J, Maezawa I, Harvey D, Jin L, et al.
Sci Rep
. 2023 May;
13(1):7816.
PMID: 37188790
Glycosylation has been found to be altered in the brains of individuals with Alzheimer's disease (AD). However, it is unknown which specific glycosylation-related pathways are altered in AD dementia. Using...