Ixaura Medina-Medina
Overview
Explore the profile of Ixaura Medina-Medina including associated specialties, affiliations and a list of published articles.
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6
Citations
68
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Recent Articles
1.
Calderon-Gonzalez K, Medina-Medina I, Haronikova L, Hernychova L, Bonczek O, Uhrik L, et al.
Biosci Rep
. 2022 Jun;
42(7).
PMID: 35674210
HDMX and its homologue HDM2 are two essential proteins for the cell; after genotoxic stress, both are phosphorylated near to their RING domain, specifically at serine 403 and 395, respectively....
2.
Hernandez-Monge J, Martinez-Sanchez M, Rousset-Roman A, Medina-Medina I, Olivares-Illana V
EMBO Rep
. 2020 Nov;
22(1):e50615.
PMID: 33185004
The retinoblastoma tumour suppressor protein (RB) regulates a number of diverse cellular functions including differentiation, angiogenesis, chromatin remodelling, senescence and apoptosis. The best-characterised function of RB is cell cycle regulation,...
3.
Uhrik L, Wang L, Haronikova L, Medina-Medina I, Rebolloso-Gomez Y, Chen S, et al.
Biochem J
. 2019 Oct;
476(21):3401-3411.
PMID: 31652301
Allosteric changes imposed by post-translational modifications regulate and differentiate the functions of proteins with intrinsic disorder regions. HDM2 is a hub protein with a large interactome and with different cellular...
4.
Medina-Medina I, Martinez-Sanchez M, Hernandez-Monge J, Fahraeus R, Muller P, Olivares-Illana V
Protein Sci
. 2018 Mar;
27(5):976-986.
PMID: 29524278
HDM2 and HDMX are two homologs essential for controlling p53 tumor suppressor activity under normal conditions. Both proteins bind different sites on the p53 N-terminus, and while HDM2 has E3...
5.
Hernandez-Monge J, Rousset-Roman A, Medina-Medina I, Olivares-Illana V
Genes Cancer
. 2017 Jan;
7(9-10):278-287.
PMID: 28050229
The orchestrated crosstalk between the retinoblastoma (RB) and p53 pathways contributes to preserving proper homeostasis within the cell. The deregulation of one or both pathways is a common factor in...
6.
Medina-Medina I, Garcia-Beltran P, de la Mora-de la Mora I, Oria-Hernandez J, Millot G, Fahraeus R, et al.
Mol Cell Biol
. 2016 May;
36(16):2195-205.
PMID: 27215386
HDM2 and HDMX are key negative regulatory factors of the p53 tumor suppressor under normal conditions by promoting its degradation or preventing its trans activity, respectively. It has more recently...