Borivoj Vojtesek
Overview
Explore the profile of Borivoj Vojtesek including associated specialties, affiliations and a list of published articles.
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Articles
158
Citations
2829
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Recent Articles
1.
Hrabal V, Stenckova M, Zavadil Kokas F, Muller P, Nenutil R, Vojtesek B, et al.
Sci Rep
. 2024 Dec;
14(1):29949.
PMID: 39622910
TP73 is a member of the TP53 gene family and produces N- and C-terminal protein isoforms through alternative promoters, alternative translation initiation and alternative splicing. Most notably, p73 protein isoforms...
2.
Pawlicka K, Henek T, Uhrik L, Hernychova L, Padariya M, Faktor J, et al.
Front Genet
. 2024 Nov;
15:1407375.
PMID: 39563734
Readthrough of a translation termination codon is regulated by ribosomal A site recognition and insertion of near-cognate tRNAs. Small molecules exist that mediate incorporation of amino acids at the stop...
3.
Simoncik O, Tichy V, Durech M, Hernychova L, Trcka F, Uhrik L, et al.
PLoS One
. 2024 Nov;
19(11):e0312524.
PMID: 39495731
Stress responses play a vital role in cellular survival against environmental challenges, often exploited by cancer cells to proliferate, counteract genomic instability, and resist therapeutic stress. Heat shock factor protein...
4.
Lopez I, Valdivia I, Vojtesek B, Fahraeus R, Coates P
Nucleic Acids Res
. 2024 Oct;
52(20):12112-12129.
PMID: 39404067
The p53 family of proteins evolved from a common ancestor into three separate genes encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each member that...
5.
Martinkova L, Zatloukalova P, Kucerikova M, Friedlova N, Tylichova Z, Zavadil-Kokas F, et al.
Cell Mol Biol Lett
. 2024 Sep;
29(1):117.
PMID: 39237877
Background: PD-L1 expression on cancer cells is an important mechanism of tumor immune escape, and immunotherapy targeting the PD-L1/PD1 interaction is a common treatment option for patients with melanoma. However,...
6.
Kocikowski M, Dziubek K, Wegrzyn K, Hrabal V, Zavadil-Kokas F, Vojtesek B, et al.
Front Immunol
. 2024 May;
15:1382576.
PMID: 38779661
Monoclonal antibodies targeting immune checkpoints have revolutionized oncology. Yet, the effectiveness of these treatments varies significantly among patients, and they are associated with unexpected adverse events, including hyperprogression. The murine...
7.
ONeill J, Mayordomo M, Mitulovic G, Al Shboul S, Bedran G, Faktor J, et al.
Mol Cell Proteomics
. 2024 Apr;
23(6):100764.
PMID: 38604503
Efforts to address the poor prognosis associated with esophageal adenocarcinoma (EAC) have been hampered by a lack of biomarkers to identify early disease and therapeutic targets. Despite extensive efforts to...
8.
Padariya M, Vojtesek B, Hupp T, Kalathiya U
Int J Mol Sci
. 2024 Mar;
25(6).
PMID: 38542156
mRNAs containing premature stop codons are responsible for various genetic diseases as well as cancers. The truncated proteins synthesized from these aberrant mRNAs are seldom detected due to the nonsense-mediated...
9.
Pokorna Z, Tylichova Z, Vojtesek B, Coates P
Sci Rep
. 2024 Mar;
14(1):7304.
PMID: 38538801
TGFβ has roles in inflammation, wound healing, epithelial to mesenchymal transition (EMT), and cancer stem cell states, and acts as a tumor suppressor gene for squamous cell carcinoma (SCC). SCCs...
10.
Biochemical evidence for conformational variants in the anti-viral and pro-metastatic protein IFITM1
Nekulova M, Wyszkowska M, Friedlova N, Uhrik L, Zavadil Kokas F, Hrabal V, et al.
Biol Chem
. 2024 Feb;
405(5):311-324.
PMID: 38379409
Interferon induced transmembrane proteins (IFITMs) play a dual role in the restriction of RNA viruses and in cancer progression, yet the mechanism of their action remains unknown. Currently, there is...