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Ivan Nagaev

Explore the profile of Ivan Nagaev including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 13
Citations 934
Followers 0
Related Specialties
Allergy & Immunology
Reproductive Medicine
Biochemistry
Top 10 Co-Authors
Lucia Mincheva-Nilsson
Olga Nagaeva
Ulrika Ottander
Eva Lundin
Ulf Smith
Emma Bjork
Pernilla Israelsson
Maria Bokarewa
Marie-Therese Vinnars
Eva Dehlin
Published In
Am J Reprod Immunol
J Immunol
J Biol Chem
PLoS One
Immun Inflamm Dis
Affiliations
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Recent Articles
1.
Endometriotic Tissue-derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis
Bjork E, Israelsson P, Nagaev I, Nagaeva O, Lundin E, Ottander U, et al.
J Immunol . 2024 Jul; 213(5):567-576. PMID: 38984872
Endometriosis, affecting 10% of women, is defined as implantation, survival, and growth of endometrium-like/endometriotic tissue outside the uterine cavity, causing inflammation, infertility, pain, and susceptibility to ovarian cancer. Despite extensive...
2.
NKG2D-mediated cytotoxicity improves after primary surgery for high-grade serous ovarian cancer
Israelsson P, Bjork E, Nagaev I, Nagaeva O, Lundin E, Mincheva-Nilsson L, et al.
Am J Reprod Immunol . 2022 Nov; 89(1):e13647. PMID: 36335434
Problem: Tumors compromise the patients' immune system to promote their own survival. We have previously reported that HGSC exosomes play a central role, downregulating NKG2D cytotoxicity. Primary surgery's effect on...
3.
Rift Valley Fever Virus Propagates in Human Villous Trophoblast Cell Lines and Induces Cytokine mRNA Responses Known to Provoke Miscarriage
Gwon Y, Nematollahi Mahani S, Nagaev I, Mincheva-Nilsson L, Evander M
Viruses . 2021 Nov; 13(11). PMID: 34835071
The mosquito-borne Rift Valley fever (RVF) is a prioritised disease that has been listed by the World Health Organization for urgent research and development of counteraction. Rift Valley fever virus...
4.
Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity
Bjork E, Vinnars M, Nagaev I, Nagaeva O, Lundin E, Ottander U, et al.
Am J Reprod Immunol . 2020 Jul; 84(4):e13298. PMID: 32623813
Problem: Endometriosis is a disease characterized by ectopic implantation of endometrium and impaired immune responses. To explore its pathogenic mechanisms, we studied the local and systemic cytokine mRNA profiles and...
5.
Cytokine mRNA and protein expression by cell cultures of epithelial ovarian cancer-Methodological considerations on the choice of analytical method for cytokine analyses
Israelsson P, Dehlin E, Nagaev I, Lundin E, Ottander U, Mincheva-Nilsson L
Am J Reprod Immunol . 2020 Apr; 84(1):e13249. PMID: 32307767
Problem: To get a comprehensive picture of cytokine expression in health and disease is difficult, cytokines are transiently and locally expressed, and protein analyses are burdened by biological modifications, technical...
6.
Enhanced Th1 and inflammatory mRNA responses upregulate NK cell cytotoxicity and NKG2D ligand expression in human pre-eclamptic placenta and target it for NK cell attack
Vinnars M, Bjork E, Nagaev I, Ottander U, Bremme K, Holmlund U, et al.
Am J Reprod Immunol . 2018 May; 80(1):e12969. PMID: 29741244
Problem: Pre-eclampsia (PE), a severe human pregnancy disorder, is associated with exaggerated systemic inflammation, enhanced cytokine production, and increased shedding of microvesicles leading to endothelial dysfunction, coagulopathy, and extensive placenta...
7.
Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity
Holm A, Nagaeva O, Nagaev I, Loizou C, Laurell G, Mincheva-Nilsson L, et al.
Immun Inflamm Dis . 2017 Aug; 5(4):541-550. PMID: 28805308
Objectives: Recurrent respiratory papillomatosis (RRP) is a relatively rare, chronic disease caused by Human Papilloma Virus (HPV) 6 and 11, and characterized by wart-like lesions in the airway affecting voice...
8.
Dynamics of cytokine mRNA expression and fecal biomarkers in school-children undergoing a double-blind placebo-controlled food challenge series
Winberg A, Nagaeva O, Nagaev I, Lundell C, Arencibia I, Mincheva-Nilsson L, et al.
Cytokine . 2016 Oct; 88:259-266. PMID: 27697703
Background: There is need for prognostic markers for symptomatic food allergy since current diagnostic methods are insufficient and/or time and labor consuming. Objective: To estimate the cytokine mRNA profiles in...
9.
Differential expression of ligands for NKG2D and DNAM-1 receptors by epithelial ovarian cancer-derived exosomes and its influence on NK cell cytotoxicity
Labani-Motlagh A, Israelsson P, Ottander U, Lundin E, Nagaev I, Nagaeva O, et al.
Tumour Biol . 2015 Nov; 37(4):5455-66. PMID: 26563374
Cancers constitutively produce and secrete into the blood and other biofluids 30-150 nm-sized endosomal vehicles called exosomes. Cancer-derived exosomes exhibit powerful influence on a variety of biological mechanisms to the...
10.
Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes
Nagaev I, Bokarewa M, Tarkowski A, Smith U
PLoS One . 2006 Dec; 1:e31. PMID: 17183659
The characteristics of human resistin (RETN) are unclear and controversial despite intensive adipose-focused research. Its transcriptional and functional similarity with the murine myeloid-specific and CCAAT/enhancer binding protein epsilon (Cebpe)-dependent gene,...