Ivan Kempson
Overview
Explore the profile of Ivan Kempson including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
483
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Recent Articles
1.
Sailo B, Garhwal A, Mishra A, Hegde M, Vishwa R, Girisa S, et al.
Biochem Pharmacol
. 2025 Mar;
:116828.
PMID: 40023449
Capsaicin (CAPS), a bioactive alkaloid derived from chili peppers, has garnered significant interest for its potential role as a combinatorial and chemosensitizing agent in cancer therapy. Numerous preclinical studies have...
2.
Liang S, Le Q, Arrua R, Turnbull T, Kempson I
ACS Biomater Sci Eng
. 2024 Dec;
11(1):623-633.
PMID: 39731574
Polymer based nanoformulations offer substantial prospects for efficacious chemotherapy delivery. Here, we developed a pH-responsive polymeric nanoparticle based on acidosis-triggered breakdown of boronic ester linkers. A biocompatible hyaluronic acid (HA)...
3.
Ghasemi M, Holmes A, Turnbull T, Kempson I
Anal Chem
. 2024 Dec;
96(52):20435-20444.
PMID: 39668546
Gold nanoparticles (AuNPs) have shown promise for applications in the diagnosis and treatment of different diseases, including cancer. Understanding the effect of AuNPs on metabolic reprogramming in cancer cells at...
4.
Atkinson J, Chopin J, Bezak E, Le H, Kempson I
Chemphyschem
. 2024 Oct;
26(3):e202400764.
PMID: 39473308
Metal nanoparticles sensitize cancers to radiotherapy however their mechanisms of action are complex. The conceptual inspiration arose from theories of physical dose deposition however various chemical and biological factors have...
5.
Atkinson J, Bezak E, Le H, Kempson I
Int J Mol Sci
. 2024 Feb;
25(4).
PMID: 38396904
Accurately characterizing DNA double-stranded breaks (DSBs) and understanding the DNA damage response (DDR) is crucial for assessing cellular genotoxicity, maintaining genomic integrity, and advancing gene editing technologies. Immunofluorescence-based techniques have...
6.
Liao Z, Hsu S, Tang S, Kempson I, Yang P, Tseng S
Pharmacol Ther
. 2023 Sep;
250:108521.
PMID: 37657673
In 2015, oncolytic virotherapy was approved for clinical use, and in 2017, recombinant adeno-associated virus (AAV) delivery was also approved. However, systemic administration remains challenging due to the limited number...
7.
Sebastian S, Hoffmann M, Howard D, Young C, Washington J, Unterweger H, et al.
Antioxidants (Basel)
. 2023 Aug;
12(8).
PMID: 37627612
Nanoparticle-based therapeutics are being clinically translated for treating cancer. Even when thought to be biocompatible, nanoparticles are being increasingly identified as altering cell regulation and homeostasis. Antioxidant pathways are important...
8.
Atkinson J, Bezak E, Le H, Kempson I
Phys Eng Sci Med
. 2023 May;
46(2):529-560.
PMID: 37160539
Particle therapies are becoming increasingly available clinically due to their beneficial energy deposition profile, sparing healthy tissues. This may be further promoted with ultra-high dose rates, termed FLASH. This review...
9.
Ghasemi M, Liang S, Luu Q, Kempson I
Methods Mol Biol
. 2023 May;
2644:15-33.
PMID: 37142913
The MTT assay is extensively used, most often to infer a measure of cytotoxicity of treatments to cells. As with any assay though, there are a number of limitations. The...
10.
Howard D, Turnbull T, Paterson D, Thierry B, Kempson I
ACS Appl Bio Mater
. 2022 Aug;
PMID: 36027561
Nanoparticle (NP) internalization by cells is complex, highly heterogeneous, and fundamentally important for nanomedicine. We report powerful probabilistic statistics from single-cell data on quantitative NP uptake of PEG-coated transferrin receptor-targeted...