Ivan Adzhubei
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Explore the profile of Ivan Adzhubei including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Jain N, Richter F, Adzhubei I, Sharp A, Gelb B
BMC Genomics
. 2023 May;
24(1):226.
PMID: 37127568
Open reading frames (ORFs) with fewer than 100 codons are generally not annotated in genomes, although bona fide genes of that size are known. Newer biochemical studies have suggested that...
2.
Cassa C, Jordan D, Adzhubei I, Sunyaev S
Genet Med
. 2018 Feb;
20(9):936-941.
PMID: 29388949
Purpose: Over 150,000 variants have been reported to cause Mendelian disease in the medical literature. It is still difficult to leverage this knowledge base in clinical practice, as many reports...
3.
Savova V, Pearl E, Boke E, Nag A, Adzhubei I, Horb M, et al.
Dev Biol
. 2017 Mar;
424(2):181-188.
PMID: 28283406
We characterize the genetic diversity of Xenopus laevis strains using RNA-seq data and allele-specific analysis. This data provides a catalogue of coding variation, which can be used for improving the...
4.
Do R, Balick D, Li H, Adzhubei I, Sunyaev S, Reich D
Nat Genet
. 2015 Jan;
47(2):126-31.
PMID: 25581429
Non-African populations have experienced size reductions in the time since their split from West Africans, leading to the hypothesis that natural selection to remove weakly deleterious mutations has been less...
5.
Adzhubei I, Jordan D, Sunyaev S
Curr Protoc Hum Genet
. 2013 Jan;
Chapter 7:Unit7.20.
PMID: 23315928
PolyPhen-2 (Polymorphism Phenotyping v2), available as software and via a Web server, predicts the possible impact of amino acid substitutions on the stability and function of human proteins using structural...
6.
Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin-Tse C, Cooney J, et al.
Genome Res
. 2012 May;
22(8):1541-8.
PMID: 22555591
Genetic mapping of mutations in model systems has facilitated the identification of genes contributing to fundamental biological processes including human diseases. However, this approach has historically required the prior characterization...
7.
Stamatoyannopoulos J, Adzhubei I, Thurman R, Kryukov G, Mirkin S, Sunyaev S
Nat Genet
. 2009 Mar;
41(4):393-5.
PMID: 19287383
Eukaryotic DNA replication is highly stratified, with different genomic regions shown to replicate at characteristic times during S phase. Here we observe that mutation rate, as reflected in recent evolutionary...
8.
Junqueira M, Spirin V, Balbuena T, Thomas H, Adzhubei I, Sunyaev S, et al.
J Proteomics
. 2008 Jul;
71(3):346-56.
PMID: 18639657
Homology-driven proteomics is a major tool to characterize proteomes of organisms with unsequenced genomes. This paper addresses practical aspects of automated homology-driven protein identifications by LC-MS/MS on a hybrid LTQ...
9.
Junqueira M, Spirin V, Balbuena T, Waridel P, Surendranath V, Kryukov G, et al.
J Proteome Res
. 2008 Jun;
7(8):3382-95.
PMID: 18558732
Only a small fraction of spectra acquired in LC-MS/MS runs matches peptides from target proteins upon database searches. The remaining, operationally termed background, spectra originate from a variety of poorly...
10.
Birney E, Stamatoyannopoulos J, Dutta A, Guigo R, Gingeras T, Margulies E, et al.
Nature
. 2007 Jun;
447(7146):799-816.
PMID: 17571346
We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the...