Iulia A Kovari
Overview
Explore the profile of Iulia A Kovari including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
227
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Recent Articles
1.
Mirza M, Alanko I, Vanmeert M, Muzzarelli K, Salo-Ahen O, Abdullah I, et al.
Eur J Pharm Sci
. 2022 May;
175:106220.
PMID: 35618201
With expanding recent outbreaks and a lack of treatment options, the Zika virus (ZIKV) poses a severe health concern. The availability of ZIKV NS2B-NS3 co-crystallized structures paved the way for...
2.
Chordia P, Dewdney T, Keusch B, Kuiper B, Ross K, Kovari I, et al.
Discoveries (Craiova)
. 2020 Apr;
2(4):e27.
PMID: 32309558
Treatment of Human Immunodeficiency Virus remains challenging due to the emergence of drug resistant strains under the selective pressure produced by standard anti-retroviral therapy. To explore the structural mechanisms of...
3.
Muzzarelli K, Kuiper B, Spellmon N, Brunzelle J, Hackett J, Amblard F, et al.
Biochemistry
. 2019 Jan;
58(7):900-907.
PMID: 30605321
Norovirus is the leading cause of acute gastroenteritis worldwide with a yearly reported 700 million cases driving a $60 billion global socioeconomic burden. With no United States Food and Drug...
4.
Kuiper B, Muzzarelli K, Keusch B, Holcomb J, Amblard F, Liu P, et al.
Infect Disord Drug Targets
. 2018 May;
18(3):224-232.
PMID: 29779487
Background: Noroviruses are the leading cause of acute gastroenteritis worldwide. Norovirus proteases, which are responsible for cleavage of the viral polyprotein, have become an attractive drug target to treat norovirus...
5.
Kuiper B, Keusch B, Dewdney T, Chordia P, Ross K, Brunzelle J, et al.
Biochem Biophys Rep
. 2017 Nov;
2:160-165.
PMID: 29124158
HIV-1 protease (PR) is a 99 amino acid protein responsible for proteolytic processing of the viral polyprotein - an essential step in the HIV-1 life cycle. Drug resistance mutations in...
6.
Kuiper B, Slater K, Spellmon N, Holcomb J, Medapureddy P, Muzzarelli K, et al.
Biochem Biophys Res Commun
. 2017 Mar;
492(4):668-673.
PMID: 28342876
Zika virus (ZIKV) is a flavivirus spread by daytime-active Aedes spp. mosquitoes such as A. aegypti and A. albopictus. Previously thought to be a mild infection, the latest ZIKV outbreak...
7.
Yedidi R, Proteasa G, Martin P, Liu Z, Vickrey J, Kovari I, et al.
J Mol Graph Model
. 2014 Aug;
53:105-111.
PMID: 25108107
Human immunodeficiency virus type-1 (HIV-1) protease, a homodimeric aspartyl protease, is a critical drug target in designing anti-retroviral drugs to treat HIV/AIDS. Multidrug-resistant (MDR) clinical isolate-769 HIV-1 protease (PDB ID:...
8.
Wang Y, Dewdney T, Liu Z, Reiter S, Brunzelle J, Kovari I, et al.
Biology (Basel)
. 2014 May;
1(1):81-93.
PMID: 24832048
Designing HIV-1 protease inhibitors that overcome drug-resistance is still a challenging task. In this study, four clinical isolates of multi-drug resistant HIV-1 proteases that exhibit resistance to all the US...
9.
Yedidi R, Liu Z, Kovari I, Woster P, Kovari L
J Mol Graph Model
. 2013 Dec;
47:18-24.
PMID: 24291501
Crystal structure of multidrug-resistant (MDR) clinical isolate 769, human immunodeficiency virus type-1 (HIV-1) protease in complex with lopinavir (LPV) (PDB ID: 1RV7) showed altered binding orientation of LPV in the...
10.
Dewdney T, Wang Y, Liu Z, Sharma S, Reiter S, Brunzelle J, et al.
Bioorg Med Chem
. 2013 Oct;
21(23):7430-4.
PMID: 24128815
Proper proteolytic processing of the HIV-1 Gag/Pol polyprotein is required for HIV infection and viral replication. This feature has made HIV-1 protease an attractive target for antiretroviral drug design for...