Ismo Ulmanen
Overview
Explore the profile of Ismo Ulmanen including associated specialties, affiliations and a list of published articles.
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18
Citations
286
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Recent Articles
1.
Kekalainen E, Lehto M, Smeds E, Pontynen N, Pekkarinen P, Ulmanen I, et al.
Immunol Lett
. 2015 Jun;
167(1):17-22.
PMID: 26112418
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by mutations in Autoimmune regulator (Aire), a transcriptional regulator of negative selection in thymus. However, Aire is also expressed in periphery, but the full...
2.
Palo J, Ulmanen I, Lukka M, Ellonen P, Sajantila A
Eur J Hum Genet
. 2009 Apr;
17(10):1336-46.
PMID: 19367325
The Finnish population in Northern Europe has been a target of extensive genetic studies during the last decades. The population is considered as a homogeneous isolate, well suited for gene...
3.
Tonooka A, Kubo T, Ichimiya S, Tamura Y, Ilmarinen T, Ulmanen I, et al.
Biochem Biophys Res Commun
. 2009 Jan;
379(3):765-70.
PMID: 19124002
During T cell development in the thymus, autoreactive T cells are deleted through a mechanism that is actively supported by medullary epithelial cells. These epithelial cells possess particular transcription factors...
4.
Palo J, Hedman M, Ulmanen I, Lukka M, Sajantila A
Forensic Sci Int Genet
. 2008 Dec;
1(2):120-4.
PMID: 19083741
Among the Finns, the levels of autosomal STR and mtDNA variation have been reported to be relatively high and evenly distributed throughout the country. In contrast, the Y-STR variation is...
5.
Pontynen N, Strengell M, Sillanpaa N, Saharinen J, Ulmanen I, Julkunen I, et al.
J Mol Med (Berl)
. 2008 Jul;
86(10):1139-52.
PMID: 18600308
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a monogenic autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene. AIRE functions as a transcriptional regulator, and it has a central role...
6.
Palo J, Pirttimaa M, Bengs A, Johnsson V, Ulmanen I, Lukka M, et al.
Int J Legal Med
. 2008 Jun;
122(6):449-56.
PMID: 18548267
The Y-chromosomal diversity among Finnish males is characterized by low diversity and substantial geographical substructuring. In a 12-locus data set (PowerPlexY), especially the eastern parts of the country showed low...
7.
Ilmarinen T, Kangas H, Kytomaa T, Eskelin P, Saharinen J, Seeler J, et al.
Mol Immunol
. 2007 Dec;
45(7):1847-62.
PMID: 18083234
AIRE (autoimmune regulator) promotes the establishment of self-tolerance by regulating gene expression in the thymus. Mutations in AIRE lead to an autoimmune disease, APECED. Here we have identified PIAS proteins...
8.
Dominguez M, Crushell E, Ilmarinen T, McGovern E, Collins S, Chang B, et al.
J Pediatr Endocrinol Metab
. 2007 Jan;
19(11):1343-52.
PMID: 17220063
Objective: To determine the Irish prevalence of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), the AIRE mutations involved and clinical features of this population. Methods: All patients were identified through paediatricians and endocrinologists...
9.
Pontynen N, Miettinen A, Arstila T, Kampe O, Alimohammadi M, Vaarala O, et al.
J Autoimmun
. 2006 Jul;
27(2):96-104.
PMID: 16820279
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, or APS1), is a monogenic autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene. The three main components of APECED are chronic mucocuteaneous candidiasis,...
10.
Turunen J, Wessman M, Forsblom C, Kilpikari R, Parkkonen M, Pontynen N, et al.
Immunogenetics
. 2006 Mar;
58(5-6):331-8.
PMID: 16552513
Mutations in the autoimmune regulator (AIRE) gene cause a recessive Mendelian disorder autoimmune polyendocrinopathy syndrome type 1 (APS-1 or autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy). APS-1 patients develop multiorgan autoimmune diseases including type...