Ismail M Hafez
Overview
Explore the profile of Ismail M Hafez including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
1340
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Recent Articles
1.
Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems
Leung A, Tam Y, Chen S, Hafez I, Cullis P
J Phys Chem B
. 2015 Jun;
119(28):8698-706.
PMID: 26087393
Previous work has shown that lipid nanoparticles (LNP) composed of an ionizable cationic lipid, a poly(ethylene glycol) (PEG) lipid, distearoylphosphatidylcholine (DSPC), cholesterol, and small interfering RNA (siRNA) can be efficiently...
2.
Degtyar V, Hafez I, Bray C, Zucker R
J Neurosci
. 2013 Mar;
33(13):5507-23.
PMID: 23536066
Soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNAREs) mediate vesicle fusion with the plasma membrane on activation by calcium binding to synaptotagmin. In the present study, we used fluorescence resonance...
3.
Leung A, Hafez I, Baoukina S, Belliveau N, Zhigaltsev I, Afshinmanesh E, et al.
J Phys Chem C Nanomater Interfaces
. 2012 Sep;
116(34):18440-18450.
PMID: 22962627
Lipid nanoparticles (LNP) containing ionizable cationic lipids are the leading systems for enabling therapeutic applications of siRNA; however, the structure of these systems has not been defined. Here we examine...
4.
Jayaraman M, Ansell S, Mui B, Tam Y, Chen J, Du X, et al.
Angew Chem Int Ed Engl
. 2012 Jul;
51(34):8529-33.
PMID: 22782619
Special (lipid) delivery: The role of the ionizable lipid pK(a) in the in vivo delivery of siRNA by lipid nanoparticles has been studied with a large number of head group...
5.
Basha G, Novobrantseva T, Rosin N, Tam Y, Hafez I, Wong M, et al.
Mol Ther
. 2011 Oct;
19(12):2186-200.
PMID: 21971424
Lipid nanoparticles (LNPs) are currently the most effective in vivo delivery systems for silencing target genes in hepatocytes employing small interfering RNA. Antigen-presenting cells (APCs) are also potential targets for...
6.
Semple S, Akinc A, Chen J, Sandhu A, Mui B, Cho C, et al.
Nat Biotechnol
. 2010 Jan;
28(2):172-6.
PMID: 20081866
We adopted a rational approach to design cationic lipids for use in formulations to deliver small interfering RNA (siRNA). Starting with the ionizable cationic lipid 1,2-dilinoleyloxy-3-dimethylaminopropane (DLinDMA), a key lipid...
7.