Islay Steele
Overview
Explore the profile of Islay Steele including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
316
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0
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Recent Articles
1.
Wang L, Steele I, Kumar J, Dimaline R, Jithesh P, Tiszlavicz L, et al.
Am J Physiol Gastrointest Liver Physiol
. 2016 Mar;
310(9):G696-704.
PMID: 26939869
Stromal cells influence epithelial function in both health and disease. Myofibroblasts are abundant stromal cells that influence the cellular microenvironment by release of extracellular matrix (ECM) proteins, growth factors, proteases,...
2.
Kumar J, Steele I, Moore A, Murugesan S, Rakonczay Z, Venglovecz V, et al.
Am J Physiol Gastrointest Liver Physiol
. 2015 May;
309(2):G78-86.
PMID: 25977510
The pyloric antral hormone gastrin plays a role in remodeling of the gastric epithelium, but the specific targets of gastrin that mediate these effects are poorly understood. Glandular epithelial cells...
3.
Kumar J, Holmberg C, Kandola S, Steele I, Hegyi P, Tiszlavicz L, et al.
PLoS One
. 2014 Aug;
9(7):e104877.
PMID: 25127029
Stromal cells such as myofibroblasts influence tumor progression. The mechanisms are unclear but may involve effects on both tumor cells and recruitment of bone marrow-derived mesenchymal stromal cells (MSCs) which...
4.
Balabanova S, Holmberg C, Steele I, Ebrahimi B, Rainbow L, Burdyga T, et al.
Carcinogenesis
. 2014 Apr;
35(8):1798-806.
PMID: 24710625
Stromal cells influence cancer progression. Myofibroblasts are an important stromal cell type, which influence the tumour microenvironment by release of extracellular matrix (ECM) proteins, proteases, cytokines and chemokines. The mechanisms...
5.
Kenny S, Steele I, Lyons S, Moore A, Murugesan S, Tiszlavicz L, et al.
Am J Physiol Gastrointest Liver Physiol
. 2013 Mar;
304(9):G814-22.
PMID: 23494120
Gastric mucosal health is maintained in response to potentially damaging luminal factors. Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) disrupt protective mechanisms leading to bleeding and ulceration. The plasminogen activator system...
6.
Holmberg C, Quante M, Steele I, Kumar J, Balabanova S, Duval C, et al.
Carcinogenesis
. 2012 May;
33(8):1553-62.
PMID: 22610072
Tumor progression has been linked to changes in the stromal environment. Myofibroblasts are stromal cells that are often increased in tumors but their contribution to cancer progression is not well...
7.
Czepan M, Rakonczay Jr Z, Varro A, Steele I, Dimaline R, Lertkowit N, et al.
Pflugers Arch
. 2011 Dec;
463(3):459-75.
PMID: 22138972
Myofibroblasts play central roles in wound healing, deposition of the extracellular matrix and epithelial function. Their functions depend on migration and proliferation within the subepithelial matrix, which results in accelerated...
8.
Norsett K, Steele I, Duval C, Sammut S, Murugesan S, Kenny S, et al.
Am J Physiol Gastrointest Liver Physiol
. 2011 Jan;
301(3):G446-53.
PMID: 21193525
Plasminogen activator inhibitor (PAI)-1 is associated with cancer progression, fibrosis and thrombosis. It is expressed in the stomach but the mechanisms controlling its expression there, and its biological role, are...
9.
Lassman D, McKie S, Gregory L, Lal S, DAmato M, Steele I, et al.
Gastroenterology
. 2010 Jan;
138(4):1514-24.
PMID: 20080096
Background & Aims: In human beings, as in most vertebrates, the release of the intestinal peptide cholecystokinin (CCK) by ingested food plays a major role both in digestion and the...
10.
Jiang L, Gonda T, Gamble M, Salas M, Seshan V, Tu S, et al.
Cancer Res
. 2008 Dec;
68(23):9900-8.
PMID: 19047171
Global hypomethylation has long been recognized as a feature of the malignant epithelial component in human carcinomas. Here we show evidence for this same type of epigenetic alteration in cancer-associated...