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Isabelle Roth

Explore the profile of Isabelle Roth including associated specialties, affiliations and a list of published articles. Areas
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Articles 25
Citations 593
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Recent Articles
1.
Dizin E, Olivier V, Roth I, Sassi A, Arnoux G, Ramakrishnan S, et al.
J Am Soc Nephrol . 2021 Oct; 32(12):3130-3145. PMID: 34615708
Background: Active sodium reabsorption is the major factor influencing renal oxygen consumption and production of reactive oxygen species (ROS). Increased sodium reabsorption uses more oxygen, which may worsen medullary hypoxia...
2.
Sassi A, Wang Y, Chassot A, Roth I, Ramakrishnan S, Olivier V, et al.
Am J Physiol Renal Physiol . 2021 Oct; 321(5):F645-F655. PMID: 34605273
Fine tuning of Na reabsorption takes place along the aldosterone-sensitive distal nephron, which includes the collecting duct (CD), where it is mainly regulated by aldosterone. In the CD, Na reabsorption...
3.
Sassi A, Wang Y, Chassot A, Komarynets O, Roth I, Olivier V, et al.
J Am Soc Nephrol . 2020 Apr; 31(5):1009-1023. PMID: 32245797
Background: Water and solute transport across epithelia can occur the transcellular or paracellular pathways. Tight junctions play a key role in mediating paracellular ion reabsorption in the kidney. In the...
4.
Komarynets O, Chassot A, Bernabeu E, Czogalla J, Roth I, Liaudet N, et al.
FASEB J . 2020 Jan; 34(2):2625-2640. PMID: 31908048
Primary cilia are nonmotile sensory organelles found on the surface of almost all kidney tubule epithelial cells. Being exposed to the tubular lumen, primary cilia are thought to be chemo-...
5.
Dizin E, Olivier V, Maire C, Komarynets O, Sassi A, Roth I, et al.
FASEB J . 2020 Jan; 34(2):2408-2424. PMID: 31908015
The mechanism of sodium retention and its location in kidney tubules may vary with time in nephrotic syndrome (NS). We studied the mechanisms of sodium retention in transgenic POD-ATTAC mice,...
6.
Roth I, Schumacher S, Basler T, Baumert K, Seitz J, Evertz F, et al.
Prog Biomater . 2018 Feb; 4(1):21-30. PMID: 29470790
Magnesium is currently under investigation as a prospective biodegradable implant material. Biodegradation of magnesium causes a release of magnesium, hydroxide ions and hydrogen gas but it can also lead to...
7.
Udwan K, Abed A, Roth I, Dizin E, Maillard M, Bettoni C, et al.
J Physiol . 2017 Sep; 595(22):6905-6922. PMID: 28940314
Key Points: Body Na content is tightly controlled by regulated urinary Na excretion. The intrarenal mechanisms mediating adaptation to variations in dietary Na intake are incompletely characterized. We confirmed and...
8.
Nunes P, Roth I, Meda P, Feraille E, Brown D, Hasler U
Proc Natl Acad Sci U S A . 2015 Jun; 112(24):E3104-13. PMID: 26045497
Cell volume homeostasis is vital for the maintenance of optimal protein density and cellular function. Numerous mammalian cell types are routinely exposed to acute hypertonic challenge and shrink. Molecular crowding...
9.
Qiao X, Roth I, Feraille E, Hasler U
Cell Cycle . 2014 Dec; 13(19):3059-75. PMID: 25486565
Coordinated cell proliferation and ability to form intercellular seals are essential features of epithelial tissue function. Tight junctions (TJs) classically act as paracellular diffusion barriers. More recently, their role in...
10.
Crambert G, Ernandez T, Lamouroux C, Roth I, Dizin E, Martin P, et al.
Physiol Rep . 2014 Nov; 2(11). PMID: 25413317
Large shifts of osmolality occur in the kidney medulla as part of the urine concentrating mechanism. Hyperosmotic stress profoundly challenges cellular homeostasis and induces endoplasmic reticulum (ER) stress. Here, we...