Isabelle M L Billas
Overview
Explore the profile of Isabelle M L Billas including associated specialties, affiliations and a list of published articles.
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27
Citations
397
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Recent Articles
1.
Cai Q, Sahu R, Ueberschlag-Pitiot V, Souali-Crespo S, Charvet C, Silem I, et al.
Nat Commun
. 2024 Apr;
15(1):3563.
PMID: 38670969
Synthetic glucocorticoids (GC), such as dexamethasone, are extensively used to treat chronic inflammation and autoimmune disorders. However, long-term treatments are limited by various side effects, including muscle atrophy. GC activities...
2.
Patel A, Vilela P, Shaik T, McEwen A, Hazemann I, Brillet K, et al.
Nucleic Acids Res
. 2023 Jul;
51(16):8864-8879.
PMID: 37503845
Transcription factors, such as nuclear receptors achieve precise transcriptional regulation by means of a tight and reciprocal communication with DNA, where cooperativity gained by receptor dimerization is added to binding...
3.
Beinsteiner B, Billas I, Moras D
Front Endocrinol (Lausanne)
. 2023 Jul;
14:1197063.
PMID: 37404310
Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor (NR) family that is expressed in liver, kidney, intestine and pancreas. It is a master...
4.
Postel S, Wissler L, Johansson C, Gunnarsson A, Gordon E, Collins B, et al.
Nat Struct Mol Biol
. 2023 Feb;
30(3):286-295.
PMID: 36747092
The glucocorticoid receptor (GR) is a ligand-activated transcription factor that binds DNA and assembles co-regulator complexes to regulate gene transcription. GR agonists are widely prescribed to people with inflammatory and...
5.
Beinsteiner B, Markov G, Bourguet M, McEwen A, Erb S, Patel A, et al.
BMC Biol
. 2022 Oct;
20(1):217.
PMID: 36199108
Background: Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding...
6.
Beinsteiner B, Markov G, Erb S, Chebaro Y, McEwen A, Cianferani S, et al.
PLoS Genet
. 2021 Apr;
17(4):e1009492.
PMID: 33882063
Nuclear receptors are ligand-activated transcription factors that modulate gene regulatory networks from embryonic development to adult physiology and thus represent major targets for clinical interventions in many diseases. Most nuclear...
7.
Rovito D, Rerra A, Ueberschlag-Pitiot V, Joshi S, Karasu N, Dacleu-Siewe V, et al.
Nucleic Acids Res
. 2021 Apr;
49(8):4472-4492.
PMID: 33836079
Skeletal muscle is a dynamic tissue the size of which can be remodeled through the concerted actions of various cues. Here, we investigated the skeletal muscle transcriptional program and identified...
8.
Browning C, McEwen A, Mori K, Yokoi T, Moras D, Nakagawa Y, et al.
J Pestic Sci
. 2021 Mar;
46(1):88-100.
PMID: 33746550
The ecdysone receptor (EcR) possesses the remarkable capacity to adapt structurally to different types of ligands. EcR binds ecdysteroids, including 20-hydroxyecdysone (20E), as well as nonsteroidal synthetic agonists such as...
9.
Khalturin K, Billas I, Chebaro Y, Reitzel A, Tarrant A, Laudet V, et al.
J Steroid Biochem Mol Biol
. 2018 Jun;
184:11-19.
PMID: 29940311
Steroid hormone receptors are important regulators of development and physiology in bilaterian animals, but the role of steroid signaling in cnidarians has been contentious. Cnidarians produce steroids, including A-ring aromatic...
10.
Mohideen-Abdul K, Tazibt K, Bourguet M, Hazemann I, Lebars I, Takacs M, et al.
Front Endocrinol (Lausanne)
. 2017 Jul;
8:140.
PMID: 28676789
Most nuclear receptors (NRs) bind DNA as dimers, either as hetero- or as homodimers on DNA sequences organized as two half-sites with specific orientation and spacing. The dimerization of NRs...