Isabelle Gerin
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Explore the profile of Isabelle Gerin including associated specialties, affiliations and a list of published articles.
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30
Citations
2605
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Recent Articles
1.
Van den Bossche V, Vignau J, Vigneron E, Rizzi I, Zaryouh H, Wouters A, et al.
Nat Commun
. 2025 Jan;
16(1):1237.
PMID: 39890801
Anti-epidermal growth factor receptor (EGFR) therapy (cetuximab) shows a limited clinical benefit for patients with locally advanced or recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), due to the frequent...
2.
Paquay S, Duraffourd J, Bury M, Heremans I, Caligiore F, Gerin I, et al.
Cell Mol Life Sci
. 2024 Aug;
81(1):367.
PMID: 39174697
Hydroxylated fatty acids are important intermediates in lipid metabolism and signaling. Surprisingly, the metabolism of 4-hydroxy fatty acids remains largely unexplored. We found that both ACAD10 and ACAD11 unite two...
3.
Halbout M, Bury M, Hanet A, Gerin I, Graff J, Killian T, et al.
J Biol Chem
. 2023 Jul;
299(9):105095.
PMID: 37507022
Many transcripts are targeted by nonsense-mediated decay (NMD), leading to their degradation and the inhibition of their translation. We found that the protein SUZ domain-containing protein 1 (SZRD1) interacts with...
4.
Heremans I, Caligiore F, Gerin I, Bury M, Lutz M, Graff J, et al.
Proc Natl Acad Sci U S A
. 2022 Jan;
119(4).
PMID: 35046029
Cells are continuously exposed to potentially dangerous compounds. Progressive accumulation of damage is suspected to contribute to neurodegenerative diseases and aging, but the molecular identity of the damage remains largely...
5.
Darius T, Vergauwen M, Smith T, Gerin I, Joris V, Mueller M, et al.
Am J Transplant
. 2020 Feb;
20(8):2030-2043.
PMID: 32012434
With oxygenation proposed as a resuscitative measure during hypothermic models of preservation, the aim of this study was to evaluate the optimal start time of oxygenation during continuous hypothermic machine...
6.
Dewulf J, Gerin I, Rider M, Veiga-da-Cunha M, Van Schaftingen E, Bommer G
Biochem J
. 2019 Aug;
476(16):2427-2447.
PMID: 31416829
Most fatty acids (FAs) are straight chains and are synthesized by fatty acid synthase (FASN) using acetyl-CoA and malonyl-CoA units. Yet, FASN is known to be promiscuous as it may...
7.
Gerin I, Bury M, Baldin F, Graff J, Van Schaftingen E, Bommer G
Biochem J
. 2019 Jan;
476(4):629-643.
PMID: 30670572
Repair of a certain type of oxidative DNA damage leads to the release of phosphoglycolate, which is an inhibitor of triose phosphate isomerase and is predicted to indirectly inhibit phosphoglycerate...
8.
Collard F, Baldin F, Gerin I, Bolsee J, Noel G, Graff J, et al.
Nat Chem Biol
. 2016 Jun;
12(8):601-7.
PMID: 27294321
Metabolic enzymes are very specific. However, most of them show weak side activities toward compounds that are structurally related to their physiological substrates, thereby producing side products that may be...
9.
Gerin I, Ury B, Breloy I, Bouchet-Seraphin C, Bolsee J, Halbout M, et al.
Nat Commun
. 2016 May;
7:11534.
PMID: 27194101
Mutations in genes required for the glycosylation of α-dystroglycan lead to muscle and brain diseases known as dystroglycanopathies. However, the precise structure and biogenesis of the assembled glycan are not...
10.
Liu S, Xu R, Gerin I, Cawthorn W, MacDougald O, Chen X, et al.
PLoS One
. 2014 Apr;
9(4):e95416.
PMID: 24743795
The Steroid Receptor RNA Activator (SRA) enhances adipogenesis and increases both glucose uptake and phosphorylation of Akt and FOXO1 in response to insulin. To assess the mechanism, we differentiated ST2...