Isabelle Bourget
Overview
Explore the profile of Isabelle Bourget including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
759
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0
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Recent Articles
1.
Mousset A, Lecorgne E, Bourget I, Lopez P, Jenovai K, Cherfils-Vicini J, et al.
Cancer Cell
. 2023 Apr;
41(4):757-775.e10.
PMID: 37037615
Metastasis is the major cause of cancer death, and the development of therapy resistance is common. The tumor microenvironment can confer chemotherapy resistance (chemoresistance), but little is known about how...
2.
Hagege A, Saada-Bouzid E, Ambrosetti D, Rastoin O, Boyer J, He X, et al.
Cell Rep Med
. 2022 Sep;
3(9):100659.
PMID: 36130479
Local or metastatic relapse following surgery, radiotherapy, and cisplatin is the leading cause of death in patients with head and neck squamous cell carcinoma (HNSCC). Our study shows overexpression of...
3.
Hagege A, Ambrosetti D, Boyer J, Bozec A, Doyen J, Chamorey E, et al.
Theranostics
. 2021 Oct;
11(19):9571-9586.
PMID: 34646387
Head and neck squamous cell carcinoma (HNSCC) represent the 4 most aggressive cancer. 50% of patients relapse to the current treatments combining surgery, radiotherapy and cisplatin and die two years...
4.
Bertero T, Oldham W, Grasset E, Bourget I, Boulter E, Pisano S, et al.
Cell Metab
. 2018 Oct;
29(1):124-140.e10.
PMID: 30293773
Dysregulation of extracellular matrix (ECM) deposition and cellular metabolism promotes tumor aggressiveness by sustaining the activity of key growth, invasion, and survival pathways. Yet mechanisms by which biophysical properties of...
5.
Grasset E, Bertero T, Bozec A, Friard J, Bourget I, Pisano S, et al.
Cancer Res
. 2018 Jul;
78(18):5229-5242.
PMID: 30026329
In squamous cell carcinoma (SCC), tissue invasion by collectively invading cells requires physical forces applied by tumor cells on their surrounding extracellular matrix (ECM). Cancer-related ECM is composed of thick...
6.
Ponzio G, Rezzonico R, Bourget I, Allan R, Nottet N, Popa A, et al.
J Biol Chem
. 2017 Jun;
292(30):12483-12495.
PMID: 28596382
Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Although some of the early events involved in this pathology have been identified, the subsequent steps leading...
7.
Bonan S, Albrengues J, Grasset E, Kuzet S, Nottet N, Bourget I, et al.
Oncotarget
. 2016 Dec;
8(1):1304-1320.
PMID: 27901489
Acto-myosin contractility in carcinoma-associated fibroblasts leads to assembly of the tumor extracellular matrix. The pro-inflammatory cytokine LIF governs fibroblast activation in cancer by regulating the myosin light chain 2 activity....
8.
Albrengues J, Bertero T, Grasset E, Bonan S, Maiel M, Bourget I, et al.
Nat Commun
. 2015 Dec;
6:10204.
PMID: 26667266
Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a proinvasive phenotype, which promotes extracellular matrix remodelling and collective invasion of...
9.
Brahimi-Horn M, Giuliano S, Saland E, Lacas-Gervais S, Sheiko T, Pelletier J, et al.
Cancer Metab
. 2015 Sep;
3:8.
PMID: 26322231
Background: Mitochondria are more than just the powerhouse of cells; they dictate if a cell dies or survives. Mitochondria are dynamic organelles that constantly undergo fusion and fission in response...
10.
Albrengues J, Bourget I, Pons C, Butet V, Hofman P, Tartare-Deckert S, et al.
Cell Rep
. 2014 May;
7(5):1664-1678.
PMID: 24857661
Signaling crosstalk between tumor cells and fibroblasts confers proinvasive properties to the tumor microenvironment. Here, we identify leukemia inhibitory factor (LIF) as a tumor promoter that mediates proinvasive activation of...