Isabel Risch
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Explore the profile of Isabel Risch including associated specialties, affiliations and a list of published articles.
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8
Citations
94
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Recent Articles
1.
Chen H, Ferguson C, Mitchell D, Risch I, Titus A, Paulo J, et al.
Cell Rep
. 2025 Jan;
44(2):115231.
PMID: 39862434
Mutation or deletion of the deubiquitinase USP7 causes Hao-Fountain syndrome (HAFOUS), which is characterized by speech delay, intellectual disability, and aggressive behavior and highlights important unknown roles of USP7 in...
2.
Raynor J, Collins N, Shi H, Guy C, Saravia J, Lim S, et al.
Immunity
. 2024 Oct;
57(11):2597-2614.e13.
PMID: 39406246
Nutrient availability and organelle biology direct tissue homeostasis and cell fate, but how these processes orchestrate tissue immunity remains poorly defined. Here, using in vivo CRISPR-Cas9 screens, we uncovered organelle...
3.
Yan K, Condori J, Ma Z, Metais J, Ju B, Ding L, et al.
Sci Adv
. 2023 Oct;
9(40):eadg9959.
PMID: 37801507
Lentiviral vector (LV)-based gene therapy holds promise for a broad range of diseases. Analyzing more than 280,000 vector integration sites (VISs) in 273 samples from 10 patients with X-linked severe...
4.
Su W, Saravia J, Risch I, Rankin S, Guy C, Chapman N, et al.
Nat Immunol
. 2023 Sep;
24(10):1735-1747.
PMID: 37679549
Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by innate immune-mediated inflammation, but functional and mechanistic effects of the adaptive immune system remain unclear. Here we identify brain-resident CD8 T...
5.
Dong X, Ding L, Thrasher A, Wang X, Liu J, Pan Q, et al.
Nat Commun
. 2023 May;
14(1):2581.
PMID: 37142594
Many signaling and other genes known as "hidden" drivers may not be genetically or epigenetically altered or differentially expressed at the mRNA or protein levels, but, rather, drive a phenotype...
6.
Ding L, Shi H, Qian C, Burdyshaw C, Veloso J, Khatamian A, et al.
Res Sq
. 2023 Feb;
PMID: 36747874
The sparse nature of single-cell omics data makes it challenging to dissect the wiring and rewiring of the transcriptional and signaling drivers that regulate cellular states. Many of the drivers,...
7.
Ding L, Shi H, Qian C, Burdyshaw C, Veloso J, Khatamian A, et al.
bioRxiv
. 2023 Feb;
PMID: 36747870
The sparse nature of single-cell omics data makes it challenging to dissect the wiring and rewiring of the transcriptional and signaling drivers that regulate cellular states. Many of the drivers,...
8.
Blanco D, Chapman N, Raynor J, Xu C, Su W, Kc A, et al.
Nat Cell Biol
. 2022 Oct;
24(11):1642-1654.
PMID: 36302969
Phosphatase and tensin homologue (PTEN) is frequently mutated in human cancer, but its roles in lymphopoiesis and tissue homeostasis remain poorly defined. Here we show that PTEN orchestrates a two-step...
9.
Long L, Wei J, Lim S, Raynor J, Shi H, Connelly J, et al.
Nature
. 2021 Nov;
600(7888):308-313.
PMID: 34795452
Nutrients are emerging regulators of adaptive immunity. Selective nutrients interplay with immunological signals to activate mechanistic target of rapamycin complex 1 (mTORC1), a key driver of cell metabolism, but how...