Isabel K Macdonald
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Explore the profile of Isabel K Macdonald including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
383
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Recent Articles
1.
Macdonald I, Parsy-Kowalska C, Chapman C
Trends Cancer
. 2017 Jul;
3(3):198-213.
PMID: 28718432
Cancer cells can induce an immunological response resulting in the production of tumor-associated (TA) autoantibodies. These serum immunobiomarkers have been detected for a range of cancers at an early stage...
2.
Middleton C, Irving W, Robertson J, Murray A, Parsy-Kowalska C, Macdonald I, et al.
PLoS One
. 2014 Aug;
9(8):e103867.
PMID: 25093332
Background: Individuals with liver disease, and especially those with Hepatitis B or C, are at an increased risk of developing hepatocellular carcinoma (HCC) which is the third most common cause...
3.
Macdonald I, Murray A, Healey G, Parsy-Kowalska C, Allen J, McElveen J, et al.
PLoS One
. 2012 Dec;
7(12):e51002.
PMID: 23272083
Background: The National Lung Screening Trial showed that CT screening for lung cancer led to a 20% reduction in mortality. However, CT screening has a number of disadvantages including low...
4.
Macdonald I, Allen J, Murray A, Parsy-Kowalska C, Healey G, Chapman C, et al.
PLoS One
. 2012 Jul;
7(7):e40759.
PMID: 22815807
An assay employing a panel of tumor-associated antigens has been validated and is available commercially (EarlyCDT®-Lung) to aid the early detection of lung cancer by measurement of serum autoantibodies. The...
5.
Chapman C, Healey G, Murray A, Boyle P, Robertson C, Peek L, et al.
Tumour Biol
. 2012 Apr;
33(5):1319-26.
PMID: 22492236
Tumor-associated autoantibodies (AAbs) have been described in patients with lung cancer, and the EarlyCDT®-Lung test that measures such AAbs is available as an aid for the early detection of lung...
6.
Flower D, Phadwal K, Macdonald I, Coveney P, Davies M, Wan S
Immunome Res
. 2010 Nov;
6 Suppl 2:S4.
PMID: 21067546
Atomistic Molecular Dynamics provides powerful and flexible tools for the prediction and analysis of molecular and macromolecular systems. Specifically, it provides a means by which we can measure theoretically that...
7.
Flower D, Macdonald I, Ramakrishnan K, Davies M, Doytchinova I
Immunome Res
. 2010 Nov;
6 Suppl 2:S1.
PMID: 21067543
Immunoinformatics is an emergent branch of informatics science that long ago pullulated from the tree of knowledge that is bioinformatics. It is a discipline which applies informatic techniques to problems...
8.
Macdonald I, Harkiolaki M, Hunt L, Connelley T, Carroll A, MacHugh N, et al.
PLoS Pathog
. 2010 Oct;
6(10):e1001149.
PMID: 20976198
T cell receptor (TCR) recognition of peptide-MHC class I (pMHC) complexes is a crucial event in the adaptive immune response to pathogens. Peptide epitopes often display a strong dominance hierarchy,...
9.
Walshe V, Hattotuwagama C, Doytchinova I, Wong M, Macdonald I, Mulder A, et al.
PLoS One
. 2009 Dec;
4(11):e8095.
PMID: 19956609
Background: Predictive models of peptide-Major Histocompatibility Complex (MHC) binding affinity are important components of modern computational immunovaccinology. Here, we describe the development and deployment of a reliable peptide-binding prediction method...
10.
Metcalfe C, Macdonald I, Murphy E, Brown K, Raven E, Moody P
J Biol Chem
. 2007 Dec;
283(10):6193-200.
PMID: 18056997
Isoniazid (INH, isonicotinic acid hydrazine) is one of only two therapeutic agents effective in treating tuberculosis. This prodrug is activated by the heme enzyme catalase peroxidase (KatG) endogenous to Mycobacterium...